DNA Binding Motif

						

			
Accessions: MEF2B_full (HumanTF 1.0), MA0660.1 (JASPAR 2024)

			
Names: MEF2B
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 12
Consensus: rCTAwAAATAGm
Weblogo: 
PSSM: P0      A      C      G      T
01   1385     72   1766    505      r
02     18   3150      0     12      C
03      0     25      0   3150      T
04   3150      0      0     15      A
05   1495      2      0   1655      w
06   3150      0     12    710      A
07   3150      3      2    143      A
08   3150      0      0     45      A
09      0      0      0   3150      T
10   3150      3      2      3      A
11     98     19   3150      3      G
12   1013   2138     99    506      m
Type: Heterodimer
Binding TFs: MEF2B_full (SRF-type transcription factor (DNA-binding and dimerisation domain))
Q02080 (SRF-type transcription factor (DNA-binding and dimerisation domain))
Q02080
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Katoh Y., Molkentin J. D., Dave V., Olson E. N., Periasamy M. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.. J. Biol. Chem. 273:1511-1518 (1998). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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