DNA Binding Motif

						

			
Accessions: POU6F2_DBD_1 (HumanTF 1.0), MA0793.1 (JASPAR 2024)

			
Names: POU6F2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: asCTmATTAw
Weblogo: 
PSSM: P0      A      C      G      T
01   1848    321    582    546      a
02    714   1181   2116    266      s
03    239   3297    219    257      C
04     75     64    114   3297      T
05   1192   2105     50     81      m
06   3297     75      0     21      A
07      0      4      0   3297      T
08      0     12     41   3297      T
09   3297     27     22     53      A
10   1268    546    205   1278      w
Type: Heterodimer
Binding TFs: POU6F2_DBD (Homeobox domain, Pou domain - N-terminal to homeobox domain)
P78424 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
P78424
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Rhee J. M., Gruber C. A., Brodie T. B., Trieu M., Turner E. E. Highly cooperative homodimerization is a conserved property of neural POU proteins. J. Biol. Chem. 273:34196-34205 (1998). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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