DNA Binding Motif

						

			
Accessions: MA0525.1 (JASPAR 2024)

			
Names: TP63
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: ChIP-seq
Length: 20
Consensus: agrCawGyyCarrCwTGyyy
Weblogo: 
PSSM: P0      A      C      G      T
01   3613   1752   2372   1895      a
02   2402   1337   3599   2294      g
03   4027    544   3802   1259      r
04     19   9153    102    358      C
05   6536   1640    616    840      a
06   2926    255   1263   5188      w
07     82      0   9550      0      G
08    896   4400     74   4262      y
09   2058   4119    998   2457      y
10    437   7000   1417    778      C
11   5045   2050    208   2329      a
12   2812    989   4555   1276      r
13   4726    198   3530   1178      r
14      0   9632      0      0      C
15   5101   1856     66   2609      w
16    953    817    695   7167      T
17    225      0   9394     13      G
18    528   5454    213   3437      y
19   2379   4089    408   2756      y
20   1446   3775   1621   2790      y
Type: Heterodimer
Binding TFs: Q9H3D4 (P53 DNA-binding domain, SAM domain (Sterile alpha motif), P53 tetramerisation motif)
Q9H3D4
Binding Sites: MA0525.1.1
MA0525.1.10
MA0525.1.11
MA0525.1.12
MA0525.1.13
MA0525.1.14
MA0525.1.15
MA0525.1.16
MA0525.1.17
MA0525.1.18
MA0525.1.19
MA0525.1.2
MA0525.1.20
MA0525.1.3
MA0525.1.4
MA0525.1.5
MA0525.1.6
MA0525.1.7
MA0525.1.8
MA0525.1.9
			
Publications: Yang A, Zhu Z, Kapranov P, McKeon F, Church G.M, Gingeras T.R, Struhl K. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Molecular cell 24:593-602 (2006). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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