DNA Binding Motif

Accessions: MTF1_DBD (HumanTF 1.0), MA0863.1 (JASPAR 2024)
Names: MTF1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4; < 100 counts, HT-SELEX
Length: 14
Consensus: TTTGCACACGgCAC
Weblogo:
PSSM: P0 A C G T
01 1 0 4 50 T
02 3 5 10 40 T
03 1 1 0 53 T
04 2 1 66 0 G
05 1 71 0 0 C
06 53 0 1 1 A
07 2 69 2 0 C
08 52 3 1 1 A
09 0 67 0 0 C
10 1 0 70 1 G
11 9 2 42 10 g
12 0 63 0 8 C
13 46 10 7 2 A
14 2 62 1 3 C
Type: Heterodimer
Binding TFs: MTF1_DBD (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q14872 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q14872
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Solomon D. L. C., Amati B., Land H. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 21:5372-5376 (1993). [Pubmed]

Wang Y., Lorenzi I., Georgiev O., Schaffner W. Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration.. Biol. Chem. 385:623-632 (2004). [Pubmed]

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