DNA Binding Motif

Accessions: IRF3_full (HumanTF 1.0), MA1418.1 (JASPAR 2024)
Names: IRF3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: trimeric; SELEX cycle: 3, HT-SELEX
Length: 21
Consensus: ssrrAAmGGAAACCGAAACyr
Weblogo:
PSSM: P0 A C G T
01 4596 6118 7839 4120 s
02 3597 7115 9273 2952 s
03 8451 700 14773 2099 r
04 12887 17 9047 629 r
05 18311 83 3484 2153 A
06 19157 214 193 377 A
07 14210 14600 5575 6865 m
08 288 7338 26852 3058 G
09 154 14 27999 19 G
10 19385 15 55 10 A
11 19350 15 59 54 A
12 19428 22 43 324 A
13 423 18363 1150 864 C
14 711 18316 3396 2348 C
15 394 8 27995 8 G
16 19322 137 83 26 A
17 19386 51 36 486 A
18 19410 84 56 787 A
19 569 17758 3274 516 C
20 4482 12661 4797 20225 y
21 8274 2072 10606 2389 r
Type: Heterodimer
Binding TFs: Q14653 (Interferon regulatory factor transcription factor, Interferon-regulatory factor 3)
IRF3_full (Interferon regulatory factor transcription factor, Interferon-regulatory factor 3)
Q14653
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Lin R., Genin P., Mamane Y., Hiscott J. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Mol. Cell. Biol. 20:6342-6353 (2000). [Pubmed]

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.