DNA Binding Motif

						

			
Accessions: SPDEF_full_1 (HumanTF 1.0), MA0686.1 (JASPAR 2024)

			
Names: SPDEF
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 11
Consensus: AmCCGGATgTr
Weblogo: 
PSSM: P0      A      C      G      T
01   4628    101    176    912      A
02   1890   2737    536     77      m
03     52   4628     92      0      C
04    237   4628      1      1      C
05      2      2   4628      0      G
06      6      0   4628      8      G
07   4628      0      6      2      A
08    532     69     11   4628      T
09   1566    601   4628     66      g
10     58   1345     28   4628      T
11   1911    568   1339    810      r
Type: Heterodimer
Binding TFs: O95238 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
SPDEF_full (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
O95238
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Pal M, Koul S, Koul HK. The transcription factor sterile alpha motif (SAM) pointed domain-containing ETS transcription factor (SPDEF) is required for E-cadherin expression in prostate cancer cells. J Biol Chem 288:12222-31 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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