DNA Binding Motif

						

			
Accessions: EGR1_full (HumanTF 1.0), MA0162.3 (JASPAR 2024)

			
Names: EGR1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 14
Consensus: wACGCCCACGCAhw
Weblogo: 
PSSM: P0      A      C      G      T
01    461    391    193    648      w
02   1166    394      3     18      A
03     11   1616      3      6      C
04     39      0   2087      0      G
05      0   1630      0      0      C
06      0   1645      0     13      C
07      0   1642      0     34      C
08   1221    307      7      0      A
09      0   1650      0      1      C
10      0      0   2156      2      G
11      0   1654      0     13      C
12   1308     20    160     30      A
13    482    458    104    596      h
14    510    211    181    778      w
Type: Heterodimer
Binding TFs: EGR1_full / P18146 (Zinc finger, C2H2 type, Domain of unknown function (DUF3432), Domain of unknown function (DUF3446), Zinc-finger double domain, C2H2-type zinc finger)
P18146
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Meng X, Brodsky M.H, Wolfe S.A. A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors. Nature biotechnology 23:988-94 (2005). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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