DNA Binding Motif

Accessions: ComK_2 (DBTBS 1.0)
Names: ComK_2
Organisms: Bacillus subtilis
Libraries: DBTBS 1.0 1
1 Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic acids research 36:D93-6 (2008). [Pubmed]
Length: 4
Consensus: TTTT
Weblogo:
PSSM: P0 A C G T
01 0.04 0 0 0.96 T
02 0.04 0 0 0.96 T
03 0.11 0.09 0 0.80 T
04 0 0.20 0 0.80 T
Binding TFs: ComK (Basic membrane protein)
Binding Sites: addB_1
addB_2
comC_1
comC_2
comEA_1
comEA_2
comFA_1
comFA_2
comGA_1
comGA_2
comK_3
comK_4
cspB_1
nucA_1
nucA_2
radC_1
radC_2
rapH_1
recA_1
recA_2
recA_3
recA_4
rok_1
rok_2
smf_1
smf_2
thdF_1
thdF_2
ybdK_1
ybdK_2
yhjB_1
yhjB_2
yneB_1
yneB_2
yvrP_1
yvrP_2
ywpH_1
ywpH_2
yyaF_1
yyaF_2
Publications: Haijema B.J, Hamoen L.W, Kooistra J, Venema G, van Sinderen D. Expression of the ATP-dependent deoxyribonuclease of Bacillus subtilis is under competence-mediated control. Molecular microbiology 15:203-11 (1995). [Pubmed]

Hamoen L.W, Van Werkhoven A.F, Bijlsma J.J, Dubnau D, Venema G. The competence transcription factor of Bacillus subtilis recognizes short A/T-rich sequences arranged in a unique, flexible pattern along the DNA helix. Genes & development 12:1539-50 (1998). [Pubmed]

Guillen N, Weinrauch Y, Dubnau D.A. Cloning and characterization of the regulatory Bacillus subtilis competence genes comA and comB. Journal of bacteriology 171:5354-61 (1989). [Pubmed]

van Sinderen D, ten Berge A, Hayema B.J, Hamoen L, Venema G. Molecular cloning and sequence of comK, a gene required for genetic competence in Bacillus subtilis. Molecular microbiology 11:695-703 (1994). [Pubmed]

van Sinderen D, Luttinger A, Kong L, Dubnau D, Venema G, Hamoen L. comK encodes the competence transcription factor, the key regulatory protein for competence development in Bacillus subtilis. Molecular microbiology 15:455-62 (1995). [Pubmed]

Londoño-Vallejo J.A, Dubnau D. comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases. Molecular microbiology 9:119-31 (1993). [Pubmed]

Liu J, Zuber P. A molecular switch controlling competence and motility: competence regulatory factors ComS, MecA, and ComK control sigmaD-dependent gene expression in Bacillus subtilis. Journal of bacteriology 180:4243-51 (1998). [Pubmed]

Ogura M, Yamaguchi H, Kobayashi K, Ogasawara N, Fujita Y, Tanaka T. Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK. Journal of bacteriology 184:2344-51 (2002). [Pubmed]

Roggiani M, Hahn J, Dubnau D. Suppression of early competence mutations in Bacillus subtilis by mec mutations. Journal of bacteriology 172:4056-63 (1990). [Pubmed]

Kong L, Siranosian K.J, Grossman A.D, Dubnau D. Sequence and properties of mecA, a negative regulator of genetic competence in Bacillus subtilis. Molecular microbiology 9:365-73 (1993). [Pubmed]

Kong L, Dubnau D. Regulation of competence-specific gene expression by Mec-mediated protein-protein interaction in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America 91:5793-7 (1994). [Pubmed]

Hahn J, Luttinger A, Dubnau D. Regulatory inputs for the synthesis of ComK, the competence transcription factor of Bacillus subtilis. Molecular microbiology 21:763-75 (1996). [Pubmed]

Berka R.M, Hahn J, Albano M, Draskovic I, Persuh M, Cui X, Sloma A, Widner W, Dubnau D. Microarray analysis of the Bacillus subtilis K-state: genome-wide expression changes dependent on ComK. Molecular microbiology 43:1331-45 (2002). [Pubmed]

van Sinderen D, Venema G. comK acts as an autoregulatory control switch in the signal transduction route to competence in Bacillus subtilis. Journal of bacteriology 176:5762-70 (1994). [Pubmed]

Haijema B.J, van Sinderen D, Winterling K, Kooistra J, Venema G, Hamoen L.W. Regulated expression of the dinR and recA genes during competence development and SOS induction in Bacillus subtilis. Molecular microbiology 22:75-85 (1996). [Pubmed]

van Sinderen D, Kiewiet R, Venema G. Differential expression of two closely related deoxyribonuclease genes, nucA and nucB, in Bacillus subtilis. Molecular microbiology 15:213-23 (1995). [Pubmed]

Hayashi K, Kensuke T, Kobayashi K, Ogasawara N, Ogura M. Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode inhibitors of expression of the srfA operon. Molecular microbiology 59:1714-29 (2006). [Pubmed]

Hamoen L.W, Haijema B, Bijlsma J.J, Venema G, Lovett C.M. The Bacillus subtilis competence transcription factor, ComK, overrides LexA-imposed transcriptional inhibition without physically displacing LexA. The Journal of biological chemistry 276:42901-7 (2001). [Pubmed]

Cheo D.L, Bayles K.W, Yasbin R.E. Molecular characterization of regulatory elements controlling expression of the Bacillus subtilis recA+ gene. Biochimie 74:755-62 (). [Pubmed]

Hoa T.T, Tortosa P, Albano M, Dubnau D. Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK. Molecular microbiology 43:15-26 (2002). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.