DNA Binding Motif
Accessions: | ComK_2 (DBTBS 1.0) |
Names: | ComK_2 |
Organisms: | Bacillus subtilis |
Libraries: | DBTBS 1.0 1 1 Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic acids research 36:D93-6 (2008). [Pubmed] |
Length: | 4 |
Consensus: | TTTT |
Weblogo: | |
PSSM: | P0 A C G T 01 0.04 0 0 0.96 T 02 0.04 0 0 0.96 T 03 0.11 0.09 0 0.80 T 04 0 0.20 0 0.80 T |
Binding TFs: | ComK (Basic membrane protein) |
Binding Sites: | addB_1 addB_2 comC_1 comC_2 comEA_1 comEA_2 comFA_1 comFA_2 comGA_1 comGA_2 comK_3 comK_4 cspB_1 nucA_1 nucA_2 radC_1 radC_2 rapH_1 recA_1 recA_2 recA_3 recA_4 rok_1 rok_2 smf_1 smf_2 thdF_1 thdF_2 ybdK_1 ybdK_2 yhjB_1 yhjB_2 yneB_1 yneB_2 yvrP_1 yvrP_2 ywpH_1 ywpH_2 yyaF_1 yyaF_2 |
Publications: | Haijema B.J, Hamoen L.W, Kooistra J, Venema G, van Sinderen D. Expression of the ATP-dependent deoxyribonuclease of Bacillus subtilis is under competence-mediated control. Molecular microbiology 15:203-11 (1995). [Pubmed] Hamoen L.W, Van Werkhoven A.F, Bijlsma J.J, Dubnau D, Venema G. The competence transcription factor of Bacillus subtilis recognizes short A/T-rich sequences arranged in a unique, flexible pattern along the DNA helix. Genes & development 12:1539-50 (1998). [Pubmed] Guillen N, Weinrauch Y, Dubnau D.A. Cloning and characterization of the regulatory Bacillus subtilis competence genes comA and comB. Journal of bacteriology 171:5354-61 (1989). [Pubmed] van Sinderen D, ten Berge A, Hayema B.J, Hamoen L, Venema G. Molecular cloning and sequence of comK, a gene required for genetic competence in Bacillus subtilis. Molecular microbiology 11:695-703 (1994). [Pubmed] van Sinderen D, Luttinger A, Kong L, Dubnau D, Venema G, Hamoen L. comK encodes the competence transcription factor, the key regulatory protein for competence development in Bacillus subtilis. Molecular microbiology 15:455-62 (1995). [Pubmed] Londoño-Vallejo J.A, Dubnau D. comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases. Molecular microbiology 9:119-31 (1993). [Pubmed] Liu J, Zuber P. A molecular switch controlling competence and motility: competence regulatory factors ComS, MecA, and ComK control sigmaD-dependent gene expression in Bacillus subtilis. Journal of bacteriology 180:4243-51 (1998). [Pubmed] Ogura M, Yamaguchi H, Kobayashi K, Ogasawara N, Fujita Y, Tanaka T. Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK. Journal of bacteriology 184:2344-51 (2002). [Pubmed] Roggiani M, Hahn J, Dubnau D. Suppression of early competence mutations in Bacillus subtilis by mec mutations. Journal of bacteriology 172:4056-63 (1990). [Pubmed] Kong L, Siranosian K.J, Grossman A.D, Dubnau D. Sequence and properties of mecA, a negative regulator of genetic competence in Bacillus subtilis. Molecular microbiology 9:365-73 (1993). [Pubmed] Kong L, Dubnau D. Regulation of competence-specific gene expression by Mec-mediated protein-protein interaction in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America 91:5793-7 (1994). [Pubmed] Hahn J, Luttinger A, Dubnau D. Regulatory inputs for the synthesis of ComK, the competence transcription factor of Bacillus subtilis. Molecular microbiology 21:763-75 (1996). [Pubmed] Berka R.M, Hahn J, Albano M, Draskovic I, Persuh M, Cui X, Sloma A, Widner W, Dubnau D. Microarray analysis of the Bacillus subtilis K-state: genome-wide expression changes dependent on ComK. Molecular microbiology 43:1331-45 (2002). [Pubmed] van Sinderen D, Venema G. comK acts as an autoregulatory control switch in the signal transduction route to competence in Bacillus subtilis. Journal of bacteriology 176:5762-70 (1994). [Pubmed] Haijema B.J, van Sinderen D, Winterling K, Kooistra J, Venema G, Hamoen L.W. Regulated expression of the dinR and recA genes during competence development and SOS induction in Bacillus subtilis. Molecular microbiology 22:75-85 (1996). [Pubmed] van Sinderen D, Kiewiet R, Venema G. Differential expression of two closely related deoxyribonuclease genes, nucA and nucB, in Bacillus subtilis. Molecular microbiology 15:213-23 (1995). [Pubmed] Hayashi K, Kensuke T, Kobayashi K, Ogasawara N, Ogura M. Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode inhibitors of expression of the srfA operon. Molecular microbiology 59:1714-29 (2006). [Pubmed] Hamoen L.W, Haijema B, Bijlsma J.J, Venema G, Lovett C.M. The Bacillus subtilis competence transcription factor, ComK, overrides LexA-imposed transcriptional inhibition without physically displacing LexA. The Journal of biological chemistry 276:42901-7 (2001). [Pubmed] Cheo D.L, Bayles K.W, Yasbin R.E. Molecular characterization of regulatory elements controlling expression of the Bacillus subtilis recA+ gene. Biochimie 74:755-62 (). [Pubmed] Hoa T.T, Tortosa P, Albano M, Dubnau D. Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK. Molecular microbiology 43:15-26 (2002). [Pubmed] |
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