DNA Binding Motif

						

			
Accessions: GLIS2_DBD (HumanTF 1.0), MA0736.1 (JASPAR 2024)

			
Names: GLIS2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 14
Consensus: kACCCCCCrCramG
Weblogo: 
PSSM: P0      A      C      G      T
01     74    179    929    439      k
02    813     94    130      1      A
03      3   1072      3      5      C
04      4   1074      0      1      C
05      7   1074      0     14      C
06      2   1087      0      0      C
07     56   1061      0      4      C
08     52   1056      1     99      C
09    412     12    915     50      r
10      3   1080     28     69      C
11    459     36    909     64      r
12    484     16    234    228      a
13    407    265    112    197      m
14     15    187   1051     63      G
Type: Heterodimer
Binding TFs: GLIS2_DBD (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q9BZE0 (Zinc finger, C2H2 type, Zinc-finger double domain)
Q9BZE0
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Lichti-Kaiser K, ZeRuth G, Kang HS, Vasanth S, Jetten AM. Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease. Vitam Horm : (2012;88:141-71.). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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