DNA Binding Motif

						

			
Accessions: XBP1_DBD_2 (HumanTF 1.0), MA0844.1 (JASPAR 2024)

			
Names: XBP1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 14
Consensus: wrkGmCACGTCAkc
Weblogo: 
PSSM: P0      A      C      G      T
01   4396    558    801   2467      w
02   3270   1017   2413   1780      r
03   1104   1191   2669   3999      k
04    974    367   9168   2321      G
05   3699   3809     59    247      m
06    167   7169    222    442      C
07   7840     17    276    118      A
08      9   7356      2     10      C
09     52      0  11353     10      G
10      0     16      8   9107      T
11    380   7264     47     35      C
12   8004     48    173     92      A
13    230   2273   3157   6389      k
14    989   6313   1217   1250      c
Type: Heterodimer
Binding TFs: P17861 (bZIP transcription factor, Basic region leucine zipper)
XBP1_DBD (bZIP transcription factor, Basic region leucine zipper)
P17861
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Yamamoto K, Yoshida H, Kokame K, Kaufman RJ, Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem 136:343-50 (2004). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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