DNA Binding Motif
| Accessions: | PHOX2B_full (HumanTF 1.0), MA0681.1 (JASPAR 2024) |
| Names: | PHOX2B |
| Organisms: | Homo sapiens, Mus musculus |
| Libraries: | HumanTF 1.0 1, JASPAR 2024 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | Site type: dimeric; SELEX cycle: 3, HT-SELEX |
| Length: | 11 |
| Consensus: | TAAyyyAATTA |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 3604 1710 611 23359 T 02 23359 270 2656 1151 A 03 23359 25 63 4 A 04 1784 9263 905 23359 y 05 955 10961 5380 12398 y 06 3134 10392 2149 12967 y 07 23359 1110 4248 604 A 08 23359 214 394 102 A 09 0 9 0 23359 T 10 1514 1130 50 23359 T 11 23359 202 1102 2912 A |
| Type: | Heterodimer |
| Binding TFs: | Q99453 (Homeobox domain) PHOX2B_full (Homeobox domain) Q99453 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Vincentz JW, VanDusen NJ, Fleming AB, Rubart M, Firulli BA, Howard MJ, Firulli AB. A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis. J Neurosci 32:2110-20 (2012). [Pubmed] |
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