DNA Binding Motif

Accessions: 6ee8_F (3D-footprint 20231221)
Names: RNA polymerase sigma factor SigA
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter
Length: 27
Consensus: CTTGACTnnnnnnnnnnnnnTnnnTTA
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 9 11 9 67 T
03 0 0 0 96 T
04 0 0 96 0 G
05 96 0 0 0 A
06 0 96 0 0 C
07 9 9 9 69 T
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 24 24 24 24 n
13 24 24 24 24 n
14 24 24 24 24 n
15 24 24 24 24 n
16 24 24 24 24 n
17 24 24 24 24 n
18 24 24 24 24 n
19 24 24 24 24 n
20 24 24 24 24 n
21 11 9 9 67 T
22 24 24 24 24 n
23 24 24 24 24 n
24 24 24 24 24 n
25 0 0 0 96 T
26 0 0 0 96 T
27 96 0 0 0 A
Binding TFs: 6ee8_F (Sigma-70 factor, region 1.2, Sigma-70 region 3, Sigma-70 region 2 , Sigma-70, region 4)
Binding Sites: 6ee8_P
6ee8_O
Publications: Boyaci H, Chen J, Jansen R, Darst SA, Campbell EA. Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature 565:382-385 (2019). [Pubmed]

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