DNA Binding Motif

Accessions: 3m9e_AB (3D-footprint 20231221)
Names: Thyroid hormone receptor beta
Organisms: Rattus norvegicus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Thyroid hormone beta DNA binding domain homodimer with inverted palindrome TRE
Length: 18
Consensus: TGACCtnnnnnnrGGTCA
Weblogo:
PSSM: P0 A C G T
01 8 9 9 70 T
02 0 0 96 0 G
03 73 11 6 6 A
04 0 96 0 0 C
05 0 96 0 0 C
06 9 21 6 60 t
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 24 24 24 24 n
13 59 3 28 6 r
14 0 0 96 0 G
15 0 0 96 0 G
16 6 6 4 80 T
17 0 96 0 0 C
18 86 3 3 4 A
Type: Heterodimer
Binding TFs: 3m9e_A (Zinc finger, C4 type (two domains))
3m9e_B (Zinc finger, C4 type (two domains))
Binding Sites: 3m9e_C / 3m9e_D
Publications: Chen Y, Young M.A. Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element. Molecular endocrinology (Baltimore, Md.) 24:1650-64 (2010). [Pubmed]

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