DNA Binding Motif

						

			
Accessions: RFX3_DBD_1 (HumanTF 1.0), MA0798.1 (JASPAR 2024)

			
Names: RFX3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 16
Consensus: sGTTrCCATGGyAACs
Weblogo: 
PSSM: P0      A      C      G      T
01   2881   7618   6511   4635      s
02   3237     47  33147    184      G
03    368    699    338  25178      T
04   5844   3781    129  21627      T
05   7660   1093  13832   3320      r
06     46  15003    484   1462      C
07      1  14712     47   4144      C
08  18969    393    569   1490      A
09   1771    376    326  24231      T
10   8516     81  27877      2      G
11   6275    766  29307     34      G
12   2934   9365    969   5558      y
13  17869    110   3429   3611      A
14  19507    171    522     98      A
15     95  15778     26    842      C
16   4359   7051   9040   1611      s
Type: Heterodimer
Binding TFs: RFX3_DBD (RFX DNA-binding domain)
P48380 (RFX DNA-binding domain, RFX1 transcription activation region      )
P48380
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W. A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol. Cell. Biol. 16:4486-4494 (1996). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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