DNA Binding Motif

Accessions: 1efa_AB (3D-footprint 20231221)
Names: LAC REPRESSOR
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: CRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF
Length: 15
Consensus: TGTGAGCGCTCACAA
Weblogo:
PSSM: P0 A C G T
01 4 4 6 82 T
02 0 0 96 0 G
03 0 0 0 96 T
04 4 1 91 0 G
05 78 6 4 8 A
06 4 0 91 1 G
07 0 96 0 0 C
08 0 0 96 0 G
09 4 82 4 6 C
10 1 4 0 91 T
11 4 82 4 6 C
12 79 0 17 0 A
13 0 96 0 0 C
14 96 0 0 0 A
15 69 11 8 8 A
Type: Heterodimer
Binding TFs: 1efa_A (Bacterial regulatory proteins, lacI family, Periplasmic binding proteins and sugar binding domain of LacI family, Periplasmic binding protein-like domain, Periplasmic binding protein domain)
1efa_B (Bacterial regulatory proteins, lacI family, Periplasmic binding proteins and sugar binding domain of LacI family, Periplasmic binding protein-like domain, Periplasmic binding protein domain)
Binding Sites: 1efa_D
1efa_E
Publications: Bell C.E, Lewis M. A closer view of the conformation of the Lac repressor bound to operator. Nature structural biology 7:209-14 (2000). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.