DNA Binding Motif

						

			
Accessions: HNF1A_full (HumanTF 1.0), MA0046.2 (JASPAR 2024)

			
Names: HNF1A
Organisms: Homo sapiens, Vertebrata
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 2, HT-SELEX
Length: 15
Consensus: arTTAATsATTAACw
Weblogo: 
PSSM: P0      A      C      G      T
01   5209   2441   3490   3009      a
02   6981    415   7168    636      r
03    376   1060    903  14149      T
04   2914   2170    544  14149      T
05  14149      3    246     14      A
06  14149    633      8    364      A
07   1274    423      7  14149      T
08   3340   3750   4540   2518      s
09  14149      9    339    651      A
10    711     13    845  14149      T
11     42    228      4  14149      T
12  14149    237   1337   1638      A
13  14149    695   1095    174      A
14   1488  14149    655    914      C
15   3972   3427   2275   4475      w
Type: Heterodimer
Binding TFs: P20823 (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus, Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
HNF1A_full (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus, Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
P20823
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Tronche F, Ringeisen F, Blumenfeld M, Yaniv M, Pontoglio M. Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome. Journal of molecular biology 266:231-45 (1997). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.