DNA Binding Motif

Accessions: 1au7_AB (3D-footprint 20231221)
Names: PROTEIN PIT-1
Organisms: Rattus norvegicus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: PIT-1 MUTANT/DNA COMPLEX
Length: 14
Consensus: tcATGTATATACAT
Weblogo:
PSSM: P0 A C G T
01 10 23 10 53 t
02 10 53 12 21 c
03 96 0 0 0 A
04 0 0 0 96 T
05 0 0 96 0 G
06 0 0 0 96 T
07 96 0 0 0 A
08 0 0 0 96 T
09 96 0 0 0 A
10 0 0 0 96 T
11 96 0 0 0 A
12 0 96 0 0 C
13 85 0 0 11 A
14 0 0 0 96 T
Type: Heterodimer
Binding TFs: 1au7_A (Homeobox domain, Pou domain - N-terminal to homeobox domain)
1au7_B (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: 1au7_C
1au7_D
Publications: Jacobson E.M, Li P, Leon-del-Rio A, Rosenfeld M.G, Aggarwal A.K. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes & development 11:198-212 (1997). [Pubmed]

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