DNA Binding Motif

Accessions: 1gt0_CD (3D-footprint 20231221)
Names: OCTAMER-BINDING TRANSCRIPTION FACTOR 1
Organisms: Homo sapiens, Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of a POU/HMG/DNA ternary complex
Length: 18
Consensus: CTTTGTnnGGATGCTAAT
Weblogo:
PSSM: P0 A C G T
01 0 96 0 0 C
02 0 0 0 96 T
03 0 0 0 96 T
04 0 0 0 96 T
05 13 0 82 1 G
06 0 0 0 96 T
07 24 24 24 24 n
08 24 24 24 24 n
09 13 9 68 6 G
10 6 6 78 6 G
11 96 0 0 0 A
12 0 0 0 96 T
13 0 0 96 0 G
14 0 96 0 0 C
15 0 6 0 90 T
16 75 6 9 6 A
17 96 0 0 0 A
18 6 1 0 89 T
Type: Heterodimer
Binding TFs: 1gt0_C (Homeobox domain, Pou domain - N-terminal to homeobox domain)
1gt0_D (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: 1gt0_A
1gt0_B
Publications: Reményi A, Lins K, Nissen L.J, Reinbold R, Schöler H.R, Wilmanns M. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes & development 17:2048-59 (2003). [Pubmed]

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