DNA Binding Motif

Accessions: 6df8_A (3D-footprint 20231221)
Names: Transcriptional regulator Kaiso
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Kaiso (ZBTB33) zinc finger DNA binding domain in complex with the specific Kaiso binding sequence (KBS), pH 6.5
Length: 8
Consensus: TGGCAGGA
Weblogo:
PSSM: P0 A C G T
01 9 9 11 67 T
02 0 0 96 0 G
03 0 0 96 0 G
04 0 96 0 0 C
05 96 0 0 0 A
06 0 0 96 0 G
07 9 11 67 9 G
08 67 9 9 11 A
Binding TFs: 6df8_A (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Binding Sites: 6df8_D
6df8_E
Publications: Nikolova EN, Stanfield RL, Dyson HJ, Wright PE. A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences. Biochemistry 59:1909-1926 (2020). [Pubmed]

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