DNA Binding Motif

						

			
Accessions: PROX1_DBD (HumanTF 1.0), MA0794.1 (JASPAR 2024)

			
Names: PROX1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 12
Consensus: yAAGACGyCTTa
Weblogo: 
PSSM: P0      A      C      G      T
01    174   1503    543   1147      y
02   3367     17     94     46      A
03   3367    229     48    420      A
04     63      0   3367      1      G
05   3367     21     84      2      A
06     31   3367      0     36      C
07     15      2   3367    299      G
08     11   1692      8   1675      y
09      3   3367     12     18      C
10      4      3    128   3367      T
11     17    171     39   3367      T
12   2133    553    607     74      a
Type: Heterodimer
Binding TFs: PROX1_DBD (Homeobox prospero-like protein (PROX1))
Q92786 (Homeobox prospero-like protein (PROX1))
Q92786
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Baxter SA, Cheung DY, Bocangel P, Kim HK, Herbert K, Douville JM, Jangamreddy JR, Zhang S, Eisenstat DD, Wigle JT. Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein. Biochim Biophys Acta 1813:201-12 (2011). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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