DNA Binding Motif

Accessions: 5wc9_EF (3D-footprint 20231221)
Names: Pituitary-specific positive transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Human Pit-1 and 4xCATT DNA complex
Length: 13
Consensus: TTCATTCATTCAT
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 0 0 0 96 T
03 0 96 0 0 C
04 96 0 0 0 A
05 0 0 0 96 T
06 9 14 7 66 T
07 7 73 7 9 C
08 96 0 0 0 A
09 0 0 14 82 T
10 8 0 7 81 T
11 0 96 0 0 C
12 96 0 0 0 A
13 0 7 7 82 T
Type: Heterodimer
Binding TFs: 5wc9_E (Homeobox domain, Pou domain - N-terminal to homeobox domain)
5wc9_F (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: 5wc9_G
5wc9_H
Publications: Agarwal S, Cho TY. Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter. Nucleic Acids Res : (2017). [Pubmed]

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