DNA Binding Motif

Accessions: 2bjc_AB (3D-footprint 20231221)
Names: LACTOSE OPERON REPRESSOR
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: NMR structure of a protein-DNA complex of an altered specificity mutant of the lac repressor headpiece that mimics the gal repressor
Length: 12
Consensus: GTAAGCGCTTAC
Weblogo:
PSSM: P0 A C G T
01 5 5 81 5 G
02 6 5 5 80 T
03 80 5 6 5 A
04 96 0 0 0 A
05 0 0 96 0 G
06 0 96 0 0 C
07 0 0 96 0 G
08 0 96 0 0 C
09 0 0 0 96 T
10 5 5 6 80 T
11 80 5 6 5 A
12 5 80 6 5 C
Binding TFs: 2bjc_A / 2bjc_B (Bacterial regulatory proteins, lacI family)
Binding Sites: 2bjc_C / 2bjc_D
Publications: Kopke Salinas R, Folkers G.E, Bonvin A.M, Das D, Boelens R, Kaptein R. Altered specificity in DNA binding by the lac repressor: a mutant lac headpiece that mimics the gal repressor. Chembiochem : a European journal of chemical biology 6:1628-37 (2005). [Pubmed]

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