DNA Binding Motif

Accessions: 5mf0_A (3D-footprint 20231221)
Names: MH1 domain of human Smad4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of Smad4-MH1 bound to the GGCCG site.
Length: 7
Consensus: CGGCnCG
Weblogo:
PSSM: P0 A C G T
01 6 78 6 6 C
02 6 6 78 6 G
03 0 0 96 0 G
04 6 78 6 6 C
05 24 24 24 24 n
06 6 78 6 6 C
07 6 6 78 6 G
Binding TFs: 5mf0_A (MH1 domain)
Binding Sites: 5mf0_E / 5mf0_F
Publications: Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragón E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Márquez JA, Massagué J, Macias MJ. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun 8:2070 (2017). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.