DNA Binding Motif

Accessions: 4l18_AB (3D-footprint 20231221)
Names: Runt-related transcription factor 1
Organisms: Mus musculus, Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3)
Length: 12
Consensus: aGGATGTGGCTT
Weblogo:
PSSM: P0 A C G T
01 64 10 12 10 a
02 0 0 96 0 G
03 0 0 96 0 G
04 96 0 0 0 A
05 0 0 0 96 T
06 0 0 96 0 G
07 0 0 0 96 T
08 0 0 96 0 G
09 0 0 96 0 G
10 10 66 10 10 C
11 0 0 10 86 T
12 10 0 0 86 T
Type: Heterodimer
Binding TFs: 4l18_A (Runt domain)
4l18_B (Ets-domain)
Binding Sites: 4l18_C
4l18_D
Publications: Shrivastava T, Mino K, Babayeva N.D, Baranovskaya O.I, Rizzino A, Tahirov T.H. Structural basis of Ets1 activation by Runx1. Leukemia 28:2040-8 (2014). [Pubmed]

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