DNA Binding Motif

						

			
Accessions: CLOCK_EVX1_2_3_4 (HumanTF2 1.0)

			
Names: CLOCK_EVX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 19
Consensus: yrATwAttsmkkaCAyGTG
Weblogo: 
PSSM: P0      A      C      G      T
01     75    478     81    488      y
02    532    241    434     24      r
03    966    159     41    184      A
04    116     36     34    966      T
05    680    475    546    966      w
06    966     35     88     53      A
07    191     81    235    459      t
08    240    142    223    361      t
09    228    258    348    132      s
10    326    336    147    157      m
11    174    115    392    284      k
12    211    152    294    309      k
13    537    208    142     78      a
14    149    966      9     20      C
15    966      5    208     46      A
16      4    966     25    463      y
17    256     18    966     28      G
18      8    238     24    966      T
19      6     44    966     48      G
Type: Heterodimer
Binding TFs: CLOCK_TF1 / CLOCK_TF2 (Helix-loop-helix DNA-binding domain)
EVX1_TF1 / EVX1_TF2 (Homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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