DNA Binding Motif

Accessions: 4xrm_AB (3D-footprint 20231221)
Names: Homeobox protein Meis2
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: homodimer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA
Length: 12
Consensus: TGACAATTGTCA
Weblogo:
PSSM: P0 A C G T
01 5 6 5 80 T
02 0 0 96 0 G
03 96 0 0 0 A
04 0 96 0 0 C
05 80 5 5 6 A
06 80 6 5 5 A
07 6 5 5 80 T
08 5 6 5 80 T
09 0 0 96 0 G
10 0 0 0 96 T
11 0 96 0 0 C
12 80 5 6 5 A
Type: Heterodimer
Binding TFs: 4xrm_A (Homeobox domain, Homeobox KN domain)
4xrm_B (Homeobox domain, Homeobox KN domain)
Binding Sites: 4xrm_L
4xrm_M
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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