footprintDB - a database of transcription factors with annotated cis elements (DNA motifs and sites) and binding interfaces

Database 'UniPROBE 20160601' (Transcription Factors 501-550)

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Accessions	Names	Organisms	Description and notes
UP00619B	homeobox protein prophet of Pit-1, Pituitary-specific homeodomain factor, PROP-1, PROP1_R112Q	Homo sapiens	homeobox protein prophet of Pit-1: This gene encodes a paired-like transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-st
UP00619C	homeobox protein prophet of Pit-1, Pituitary-specific homeodomain factor, PROP-1, PROP1_R99Q	Homo sapiens	homeobox protein prophet of Pit-1: This gene encodes a paired-like transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-st
UP00619A	homeobox protein prophet of Pit-1, Pituitary-specific homeodomain factor, PROP-1, PROP1_REF	Homo sapiens	homeobox protein prophet of Pit-1: This gene encodes a paired-like transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-st
UP00266A	A230024N07Rik, AA755424, AI385634, AI843499, Homeobox protein K-2, Homeobox protein mHox, mesoderm homeobox protein 1, paired related homeobox 1, Paired-related homeobox protein 1, Pmx, Pmx1, Prrx1, PRX-1, Prx1	Mus musculus	paired related homeobox 1
UP00136A	Homeobox protein S8, Paired mesoderm homeobox protein 2, paired related 2, Prrx2, PRX-2, Prx2	Mus musculus	paired related homeobox 2
UP00508A	CG1447, D-Ptx1, Dmel\CG1447, Paired-type homeobox 1, Pituitary homeobox homolog Ptx1,	Drosophila melanogaster	Paired-type homeobox 1
UP00335A	"Proline utilization trans-activator, Put3, YKL015W"	Saccharomyces cerevisiae	"Transcriptional activator of proline utilization genes, constitutively binds PUT1 and promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binu..."
UP00321A UP00398A	"DNA-binding protein RAP1, GRF1, N1310, Rap1, Repressor/activator site-binding protein, SBF-E, TUF, TUF1, YNL216W"	Saccharomyces cerevisiae	"DNA-binding protein involved in either activation or repression of transcription, on binding site context; also binds telomere sequences and plays a role in telomeric position effect (sil..."
UP00048A	alpha, Nr1b1, RAR alpha 1, RAR-alpha, Rara, RARalpha1, retinoic acid Retinoic acid receptor alpha	Mus musculus	retinoic acid receptor, alpha
UP00253A	7530406A22Rik, E130303K03Rik, ey-1, ey1, Rax, retina and anterior neural fold Retina and anterior neural fold homeobox protein, Retinal homeobox protein Rx	Mus musculus	retina and anterior neural fold homeobox
UP00269A	Protein RDR1, Rdr1, Repressor of drug resistance protein 1, YOR380W	Saccharomyces cerevisiae	Transcriptional repressor involved in the control of multidrug resistance; negatively expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
UP00296A	Putative 95.7 kDa transcriptional regulatory protein in PAU3-AAD3 intergenic region, YCR106W	Saccharomyces cerevisiae	Zinc cluster protein involved in conferring resistance to cycloheximide
UP00302A	LPI12C, Putative transcriptional regulatory protein YPL133C, Rds2	Saccharomyces cerevisiae	Zinc cluster protein involved in conferring resistance to ketoconazole
UP00383A	hlh-24, REF-1	Caenorhabditis elegans	REgulator of Fusion: ref-1 encodes a protein with two basic (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate; in males, ref-1
UP00098A	3 (influences HLA class II expression), C230093O12Rik, MRFX3, regulatory factor Rfx3, Transcription factor RFX3	Mus musculus	regulatory factor X, 3 (influences HLA class II expression)
UP00056A	4 (influences HLA class II expression), 4933412G19Rik, NYD-sp10, regulatory factor Rfx4	Mus musculus	regulatory factor X, 4 (influences HLA class II expression)
UP00076A	2510005N23Rik, 9930116O05Rik, D130086K05Rik, regulatory factor X domain containing 2 homolog Rfxdc2	Mus musculus	regulatory factor X domain containing 2 homolog (human): AK138890
UP00288A	Putative 128.2 kDa transcriptional regulatory protein in PTM1-IXR1 intergenic region, YKL038W, YKL251	Saccharomyces cerevisiae	Glucose-responsive transcription factor that regulates expression of several glucose transporter genes in response to glucose; binds to promoters and acts both as a transcriptional activator ...
UP00193A	BC049711, Gm39, LOC194738, MGC58663, reproductive homeobox 11, Rhox11	Mus musculus	reproductive homeobox 11
UP00116A	AV213605, AW548842, Psx1, reproductive homeobox 6, Rhox6	Mus musculus	reproductive homeobox 6
UP00348A	DNA damage-responsive transcriptional repressor RPH1, Rph1, YER169W	Saccharomyces cerevisiae	Transcriptional repressor of PHR1, which is a photolyase induced by damage; binds to AG(4) (C(4)T) sequence upstream of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC...
UP00272A	26S proteasome regulatory subunit RPN4, D2840, Nuclear protein SON1, Rpn4, fusion degradation protein 5, UFD5, YDL020C	Saccharomyces cerevisiae	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally reg...
UP00286A	Chromatin structure remodeling complex protein RSC3, D9740.13, Remodel the structure chromatin complex subunit 3, Rsc3, YDR303C	Saccharomyces cerevisiae	One of 15 subunits of the 'Remodel the Structure of (RSC) complex; essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to
UP00279A	Chromatin structure remodeling complex protein RSC30, Remodel the structure of complex subunit 30, Rsc30, YHR056C	Saccharomyces cerevisiae	One of 15 subunits of the 'Remodel the Structure of (RSC) complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar...
UP00356A	Retrograde regulation protein 3, Rtg3, YBL0810, YBL103C	Saccharomyces cerevisiae	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
UP00053A	9530071D11Rik, Nr2b1, Retinoic acid receptor RXR-alpha, retinoid X receptor alpha, alpha 1, Rxra, RXRalpha1	Mus musculus	retinoid X receptor alpha: retinoid X receptor alpha (Rxra), mRNA
UP00320A	Flocculation suppression protein, Sfl1, SFL1 protein, YOR140W, YOR3339W	Saccharomyces cerevisiae	Transcription repressor involved in regulation of flocculation-related genes, inhibits transcription recruiting general corepressor Cyc8p-Tup1p to different promoters; negatively regulated by cA...
UP00342A	L8084.4, Sfp1, YLR403W, Zinc finger protein SFP1	Saccharomyces cerevisiae	Transcription factor that controls expression of many ribosome biogenesis genes response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, in...
UP00085A UP00405A	31 kDa transforming protein, Dis-1, Dis1, PU.1, SFFV proviral integration SFFV proviral integration 1 protein, Sfpi-1, Sfpi1, Spi-1, Spi1, Tcfpu1, Tfpu.1, Transcription factor PU.1	Mus musculus	SFFV proviral integration 1: Mus musculus SFFV proviral integration 1 mRNA
UP00257A	6330543G17Rik, Homeobox protein Og12X, OG-12, Paired family homeodomain protein Prx3, stature homeobox 2, Short stature homeobox protein 2, SHOT, Shox2	Mus musculus	short stature homeobox 2
UP00273A	J0922, Protein SIP4, Sip4, YJL089W	Saccharomyces cerevisiae	C6 zinc cluster transcriptional activator that binds to the carbon element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1...
UP00192A	Homeobox protein SIX1, Sine oculis homeobox homolog 1, sine oculis-related 1 homolog (Drosophila), Six1	Mus musculus	sine oculis-related homeobox 1 homolog (Drosophila)
UP00159A	Homeobox protein SIX2, Sine oculis homeobox homolog 2, sine oculis-related 2 homolog (Drosophila), Six2	Mus musculus	sine oculis-related homeobox 2 homolog (Drosophila)
UP00195A	Homeobox protein SIX3, Sine oculis homeobox homolog 3, sine oculis-related 3 homolog (Drosophila), Six3, Six3a, Six3alpha, Six3b, Six3beta	Mus musculus	sine oculis-related homeobox 3 homolog (Drosophila): Mus musculus sine oculis-related 3 homolog (Drosophila) (Six3), mRNA.
UP00199A	AI047561, Arec3, Homeobox protein SIX4, Sine oculis homeobox homolog 4, oculis-related homeobox 4 homolog (Drosophila), Six4, Skeletal muscle-specific ARE binding protein AREC3, TrexBF	Mus musculus	sine oculis-related homeobox 4 homolog (Drosophila)
UP00509A	CG3871, D-six4, Dmel\CG3871, Dsix4, Six4, six4/5	Drosophila melanogaster	Six4
UP00008A UP00388A	Homeobox protein SIX6, Optic homeobox 2, Optx2, Sine oculis homeobox 6, sine oculis-related homeobox 6 homolog (Drosophila), Six6, Six9, Six9 protein	Mus musculus	sine oculis-related homeobox 6 homolog (Drosophila)
UP00620B	homeobox protein SIX6, Homeodomain protein OPTX2, MCOPCT2, Optic homeobox 2, oculis homeobox homolog 6, SIX6_H141N, Six9	Homo sapiens	homeobox protein SIX6: The protein encoded by this gene is homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
UP00620A	homeobox protein SIX6, Homeodomain protein OPTX2, MCOPCT2, Optic homeobox 2, oculis homeobox homolog 6, SIX6_REF, Six9	Homo sapiens	homeobox protein SIX6: The protein encoded by this gene is homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
UP00620C	homeobox protein SIX6, Homeodomain protein OPTX2, MCOPCT2, Optic homeobox 2, oculis homeobox homolog 6, SIX6_T165A, Six9	Homo sapiens	homeobox protein SIX6: The protein encoded by this gene is homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
UP00313A	BRY1, Peroxide sensitivity protein POS9, Skn7, Transcription factor SKN7, YHR206W	Saccharomyces cerevisiae	Nuclear response regulator and transcription factor, part of a branched signaling system; required for optimal induction of heat-shock genes in response to oxidative stress;
UP00464A	ACR1, Sko1, Suppressor of Kinase Overexpression	Saccharomyces cerevisiae	Suppressor of Kinase Overexpression : Basic leucine zipper transcription factor the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses
UP00510A	CG6534, Dmel\CG6534, Homeobox protein NK-1, Homeobox protein slou, Nk1, NK1/S59, Protein slouch, S-59, S59/2, S59/NK-1, Slou, slou/NK1, Slouch	Drosophila melanogaster	Slouch: Slou may play a role in specifying the identity particular somatic muscles and neurons of the CNS.
UP00000A	AU022421, MAD homolog 3 (Drosophila), Madh3, mMad3, Mothers against decapentaplegic 3, Mothers against DPP homolog 3, Smad 3, Smad3	Mus musculus	MAD homolog 3 (Drosophila)
UP00294A	Smp1, Transcription factor SMP1, YBR1245, YBR182C	Saccharomyces cerevisiae	Putative transcription factor involved in regulating the response to osmotic member of the MADS-box family of transcription factors
UP00621B	MGC10182, Neural crest transcription factor Slug, Protein snail homolog 2, SLUGH1, SNAI2_D119E, WS2D, zinc finger protein SNAI2	Homo sapiens	zinc finger protein SNAI2: Transcriptional repressor that modulates both activator- and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes,
UP00621A	MGC10182, Neural crest transcription factor Slug, Protein snail homolog 2, SLUGH1, SNAI2_REF, WS2D, zinc finger protein SNAI2	Homo sapiens	zinc finger protein SNAI2: Transcriptional repressor that modulates both activator- and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes,
UP00621C	MGC10182, Neural crest transcription factor Slug, Protein snail homolog 2, SLUGH1, SNAI2_T234I, WS2D, zinc finger protein SNAI2	Homo sapiens	zinc finger protein SNAI2: Transcriptional repressor that modulates both activator- and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes,
UP00578A	ARABIDOPSIS NAC DOMAIN CONTAINING PROTEIN 12, At1g32770, F6N18_15, F6N18.15, NAC transcription factor SND1, NAC domain-containing protein 12, NAC SECONDARY WALL THICKENING PROMOTING 3, NAC012, NST3, Protein NAC SECONDARY WALL THICKENING PROMOTING 3, Protein SECONDARY WALL-ASSOCIATED NAC DOMAIN PROTEIN 1, SECONDARY WALL-ASSOCIATED NAC DOMAIN 1, SND1	Arabidopsis thaliana	NAC Domain transcription factor SND1: Transcriptional activator of genes involved biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening and lignification of sclerenchymatous fibers and secondary xylem vessels (tracheary elements). Seems to repress the secondary cell wall thickening of xylary fibers. May also regulates the secondary cell wall lignification of other t
UP00069A	Sox-1, SOX-1 protein, Sox1, SRY-box containing gene 1	Mus musculus	SRY-box containing gene 1

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