interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF CTCF ZFS2-8-HS5-1AE
(Transcriptional repressor CTCF)
referenceWang et al. 'Cell 27 1365 2017
sourceHomo sapiens
experimentX-ray (resolution=2.81, R-factor=0.225)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRYESKRTYKRTQSTRSDV

Estimated binding specificities ?

readout + contactlogo
# IC=12.429 IC/col=1.036 n_of_columns=12 specificity:   
A |   0   0   0   0   0  13   0   0   0  16  24   0
C |  96   0  96  96  96  16  96   0   0  54  24   0
G |   0  96   0   0   0  13   0   0  96  13  24  96
T |   0   0   0   0   0  54   0  96   0  13  24   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RGYG--EC--SCKGRG--TCYCKA--RGTCQAST--TC----RCSCDCVT   L                      +----------5yef_B    
                                                                              ! 
  ----------------DC--YCKG--RG--QA----TC----RCSCDCVT   L                 +----3   +-------5k5i_A    
                                                                         !    ! +-1 
  ----NGKT--WTKG------HTHG--RGTGTT--ACNAKGRG--------   L                 !    +-2 +-------1tf3_A    
                                                                  +------4      ! 
  ------EC--SGKGRGDG--YCKG--RG--QA----TC----RASCDCVT   L          !      !      +--------5k5h_A    
                                                                +-5      ! 
  ----RGST--YGYC--QC--TGSTRGYT----------------------            ! !      +---------------4is1_C    
                                                           +----6 ! 
  ----------------QA----TC--RG--RG--YCRT------------   L   !    ! +----------------------7txc_E    
                                                         --7    ! 
  ----------------NT--STNA--VT--QTSTSGKGRG----------   L   !    +-----------------------6u9q_A    
                                                           ! 
  ----QT--AG--KGRGRG--DCKG--------------------------   L   +----------------------------7n5w_A    
                                                         

home
updated Thu Dec 22 22:37:06 2022