5x2h_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF CAMPYLOBACTER JEJUNI CAS9 IN COMPLEX WITH SGRNA AND TARGET DNA (AGAAACA PAM)
reference	Nishimasu et al. 'Mol. 65 1109 2017
experiment	X-ray (resolution=2.30, R-factor=0.202)
redundant complexes	5x2g_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5x2h_A interface=628,675,677,678,680,712,713, marilafdigissigwafsendelkdcgvrifteslalprrlarsarkrlarrkarlnhlkhlianefklnyedyqsfdeslakaykgslispyelrfralnellskqdfarvilhiakrrgyddiknkekgailkaikqneeklanyqsvgeylykeyfqkfkenskeftnvrnkkesyerciaqsflkdelklifkkqrefgfsfskkfeeevlsvafykralkdfshlvgncsfftdekrapknsplafmfvaltriinllnnlkntegilytkddlnallnevlkngtltykqtkkllglsddyefkgekgtyfiefkkykefisqddlneiakditlikdeiklkkalakydlnqnqidslsklefkdhlnisfkalklvtplmlegkkydeacnelnlkvainedkkdflpafnetyykdevtnpvvlraikeyrkvlnallkkygkvhkinielggyiarlvlnytkdyldflplsdvhveaksgmltsalrhtwgfsakdrnnhlhhaidaviiayrqkvldkideifvskperkkpsgalheetfrkeeefyqsyggkegvlkalelgkirkvngkivkngdmfrvdifkhkktnkfyavpiytmdfalkvlpnkavaRskkgeikdwilmdenyefcfslykdsliliqtkdmqepefvyynafTsSTvSlivskhdnkfetlsknqkilfknanekeviaKSigiqnlkvfekyivsalgevtkaefrqredfkk
interface signature	RTSTSKS

Estimated binding specificities ?

readout + contact

# IC=1.716 IC/col=0.343 n_of_columns=5

specificity:

A |  13   6  30   6  17
C |  56   5   8  14  19
G |  14   5  52  13  22
T |  13  80   6  63  38

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --YA----YC----LCLG--NT------EGRTTA--SATT--ST--KTSG   L                        +-------5x2h_A    
                                                                          +-----2 
  ----QALAYA--AGLTMTTG--KT--------DC--SCNT--RG------   L                  !     +-------6je3_A    
                                                           +--------------3 
  RA--------RC----------------------EC----KGRA----RG   L   !              !      +------6wbr_A    
                                                         --4              +------1 
  --WA----------PGRC--------KC------FT------KARG----   L   !                     +------6joo_A    
                                                           ! 
  ------------------------QT------------------------   L   +----------------------------7utn_D

home
updated Tue Dec 19 11:50:34 2023