5thg_A : 3D-footprint complex

structure name	ENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE HIV CCR5 GENE; HARBORS 43 POINT MUTATIONS RELATIVE TO WILD-TYPE I-ONUI (I-ONUI_E-HCCR5)
reference	Hallinan et al. 'to ? ? ?
source	SYNTHETIC CONSTRUCT
experiment	X-ray (resolution=3.11, R-factor=0.226)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG endonuclease;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5thg_A interface=18,20,22,24,34,36,40,42,66,70,72,134,172,174,176,186,188,190,192,216,218,225,227,231,290, resinpwiltgftdaegSfMlRiRntnnrsvgyYtSlvfEiTlhnkdksileniqstwkvgtinnRgdgTaRlsvtrfedlkviidhfekyplitqklgdyklfkqafsvmenkehlkengikelvrikakmnWglndelkkafpenierplinknipnlkwlagftsgegTfYvHlakeasgkvYvRlRfIigqhirdknlmnslitylgcgtiQeKnrskgsMlHfivTkfsdindkiipvfqentligvkledfedwckvaklieekkhltesgldeikkiklnmnKgrvf
interface signature	SMRRYSETRTRWTYHYRRIQKMHTK

Estimated binding specificities ?

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# IC=16.780 IC/col=0.839 n_of_columns=20

specificity:

A |   6   0  24   0   0  89   0   0  96  24  24  24  16  24   1   0   0   0   6   0
C |  61   0  24  96  96   0   0   0   0  24  24  24  61  24   6   0   0   0  75  96
G |  16   0  24   0   0   0  96  96   0  24  24  24  13  24   0   0  96  96   6   0
T |  13  96  24   0   0   7   0   0   0  24  24  24   6  24  89  96   0   0   9   0

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Dendrogram of similar interfaces ?

matrix format

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updated Tue Dec 19 11:19:53 2023