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structure nameENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE ANOPHELES AGAP007280 GENE; HARBORS 38 POINT MUTATIONS RELATIVE TO WILD-TYPE I- ONUI
(I-ONUI_E-AG007820)
referenceStoddard et al. 'Nucleic 45 8621 2017
sourceSYNTHETIC CONSTRUCT
experimentX-ray (resolution=2.08, R-factor=0.223)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSIRRMLESKTNMRSWHNWRQSYLKRLWRT

Estimated binding specificities ?

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# IC=21.119 IC/col=1.056 n_of_columns=20 specificity:   
A |   8   0   4  26  92   0   0  78  96   0  96  24  74   0   0   9  96   0   0  82
C |   4   0   8   0   0   0   0   2   0   0   0  24   8   0   0   0   0   0   0   6
G |  76  96   4  70   4  96  96   8   0  96   0  24  10  96   0  87   0  96  96   4
T |   8   0  80   0   0   0   0   8   0   0   0  24   4   0  96   0   0   0   0   4
scan!

Dendrogram of similar interfaces ?

matrix format



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updated Tue Dec 19 11:17:00 2023