interface graph thumbnail
legend  pdf

structure nameENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE HUMAN TCRA GENE; HARBORS 43 POINT MUTATIONS RELATIVE TO WILD-TYPE I-ONUI
(I-ONUI_E-HTCRA)
referenceStoddard et al. 'Nucleic 45 8621 2017
sourceSYNTHETIC CONSTRUCT
experimentX-ray (resolution=2.52, R-factor=0.217)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRRRSRQTSAMRTHNKYRSRKKFWEET

Estimated binding specificities ?

readout + contactlogo
# IC=22.205 IC/col=1.009 n_of_columns=22 specificity:   
A |  77  24  66  96   0   0   0   0   0   0  96  24   0  25  73   7   0  96   0  66   0  96
C |   9  24  14   0   0  96   0   0   0   0   0  24   0   3   0   3  96   0   0   7  96   0
G |   3  24   9   0   0   0  96  96   0  96   0  24   0  61  23  81   0   0  96   7   0   0
T |   7  24   7   0  96   0   0   0  96   0   0  24  96   7   0   5   0   0   0  16   0   0
scan!

Dendrogram of similar interfaces ?

matrix format

home
updated Tue Dec 19 11:16:38 2023