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legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN NEIL1(242K) BOUND TO DUPLEX DNA CONTAINING THF
(Endonuclease 8-like 1)
referenceStovicek et al. Proc.Natl.Acad.Sci.USA 113 7792 2016
sourceHomo sapiens
experimentX-ray (resolution=2.41, R-factor=0.213)
structural superfamilyN-terminal domain of MutM-like DNA repair proteins;S13-like H2TH domain;Glucocorticoid receptor-like DNA-binding domain;
sequence familyEndonuclease VIIIlike 1, DNA bind; FormamidopyrimidineDNA glycosylase N; FormamidopyrimidineDNA glycosylase H2;
redundant complexes5itr_B 5itt_B 5ity_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureMIRFHR

Estimated binding specificities ?

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# IC=4.475 IC/col=0.895 n_of_columns=5 specificity:   
A |  96   0   0  13  13
C |   0  96   0  13  57
G |   0   0  96  16  13
T |   0   0   0  54  13
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----MG--ITRCFGHGRG   L                +------5itu_A    
                           +------------2 
  ----MG--ITRCFG--RG       !            +------6lwd_G    
                         --4 
  ----MG----RGFG--RG       !               +---3twm_A    
                           !  +------------1 
  RT--MG----RCFC--RT   L   +--3            +---6tc9_A    
                              ! 
  --QALGYA--------RG          +----------------1k3x_A    
                         

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updated Tue Dec 19 10:40:18 2023