5fmp_B : 3D-footprint complex

structure name	KSTR, TRANSCRIPTIONAL REPRESSOR OF CHOLESTEROL DEGRADATION IN MYCOBACTERIUM TUBERCULOSIS, BOUND TO THE DNA OPERATOR (HTH-TYPE TRANSCRIPTIONAL REPRESSOR KSTR)
reference	Podust et al. 'To ? ? ?
source	MYCOBACTERIUM TUBERCULOSIS
experiment	X-ray (resolution=2.26, R-factor=0.205)
structural superfamily	Homeodomain-like;
sequence family	Bacterial regulatory proteins, tetR family;
multimeric complexes	5fmp_AB 5ua1_AB
redundant complexes	5ua1_A 5ua2_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5fmp_B interface=29,30,39,40,42,44, seaqrerrkrildatmaiaskggyeavqMRavadradvAVgTlYryfpskvhllvsalgrefsridaktdrsavagatpfqrlnfmvgklnramqrnpllteamtrayvfadasaasevdqveklidsmfaramangeptedqyhiarvisdvwlsnllawltrrasatdvskrldlavrlli
interface signature	MRAVTY

Estimated binding specificities ?

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# IC=5.085 IC/col=0.726 n_of_columns=7

specificity:

A |  17  52  24  80  96   0  96
C |  19  10  24   8   0  96   0
G |  17  17  24   0   0   0   0
T |  43  17  24   8   0   0   0

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: KSTR
AACTGGAACGTGTTTCAGTT	PubMed	5fmp_AB(5.12e-12), 5ua1_AB(3.23e-10)
TNNAACNNGTTNNA	PubMed	5fmp_AB(1.50e-05), 5ua1_AB(9.82e-05)

Dendrogram of similar interfaces ?

matrix format

  
  VT--AGDT--TTYT--   L                         +5gpc_B    
                                             +-1 
  ----TTRG----YT--   L                +------2 +7jnp_A    
                                      !      ! 
  LC--RTPTPTSTYT--   L   +------------3      +6nsn_B    
                         !            ! 
  MTRGTGPT--ATYTWT   L --4            +-------5yej_B    
                         ! 
  ----TGKG----YCFA   L   +--------------------4pxi_B

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updated Tue Dec 19 10:25:45 2023