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structure nameCRYSTAL STRUCTURE OF FIS BOUND TO 27BP DNA F1-8A (AAATTAGTTTGAATTTTGAGCTAATTT)
(DNA-binding protein Fis)
referenceHancock et al. 'Plos 11 e0150189 2016
sourceEscherichia coli (strain K12) / Escherichia coli (strain K12)
experimentX-ray (resolution=2.56, R-factor=0.224)
structural superfamilyHomeodomain-like;
sequence familyBacterial regulatory protein, Fis family;
multimeric complexes3iv5_AB 3jr9_AB 3jra_AB 3jrb_AB 3jrc_AB 3jrd_AB 3jre_AB 3jrf_AB 3jrg_AB 3jrh_AB 3jri_AB 4ihv_AB 4ihw_AB 4ihx_AB 4ihy_AB 5ds9_AB 5dtd_AB 5e3l_AB 5e3m_AB 5e3n_AB 5e3o_AB 6p0s_ABE 6p0t_ABE 6p0u_ABEF
redundant complexes3iv5_A 3jr9_B 3jra_A 3jrb_A 3jrc_B 3jrd_A 3jre_A 3jrf_A 3jrg_A 3jrh_A 3jri_B 4ihv_B 4ihw_A 4ihx_B 4ihy_B 5dtd_A 5e3l_A 5e3m_A 5e3n_A 5e3o_B 6p0u_A 6p0s 6p0t
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRTRK

Estimated binding specificities ?

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# IC=4.007 IC/col=0.668 n_of_columns=6 specificity:   
A |  67   0   9  24   9  96
C |  11   0  69  24  67   0
G |   9  96   9  24   9   0
T |   9   0   9  24  11   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: F21
CCTCCPubMed5e3o_B(3.56e-04)

Dendrogram of similar interfaces ?

matrix format
  
  ------------------NGRG--TTRGKT--   L                 +-------5ds9_A    
                                         +-------------1 
  ----------------RGEC--KG--------   L   !             +-------4yrv_B    
                                       --3 
  WTQATAVTHTEGITNT--------------KT   L   !       +-------------6b6h_F    
                                         +-------2 
  WTQT--VTHTEG--------------------   L           +-------------6c04_F    
                                       

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updated Tue Dec 19 10:16:31 2023