| structure name | STRUCTURAL BASIS FOR PROCESSIVITY AND ANTIVIRAL DRUG TOXICITY IN HUMAN MITOCHONDRIAL DNA REPLICASE (DNA POLYMERASE SUBUNIT GAMMA-1) |
| reference | Szymanski et al. 'EMBO 34 1959 2015 |
| source | HOMO SAPIENS |
| experiment | X-ray (resolution=3.30, R-factor=?) |
| structural superfamily | DNA/RNA polymerases;Ribonuclease H-like; |
| sequence family | DNA polymerase family A; |
| redundant complexes | 5c53 4ztz 5c52 5c51 |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence |
No structural evidence for specific binding to DNA (<4 informative columns)
Dendrogram of similar interfaces ?
matrix format--------------------NG------RT--TT--------IGYG--YG------FG------------------------EGMCTC--NG----QT---------------------- +----------------------4ztu_A ! NGKGYGMGRCFCEC--------SGHGVC-------------------------------------------------------------------------------------------- ! +--1kln_A ! +-9 ----------------KT----------RG--NG--NG------YG--YAIGSC----YC----NGRC----------------------------QA------HG-------------- ! ! ! +-4yfu_D ! ! +-7 ----------------RC----------RA--NG--NG------YG--YT--SCYC----------------------------------NT----QT---------------------- L ! +-10 +-6vdd_A +-----17 ! ! ------------------KA------------NT------------------------------------------------------------QG--------HT-------------- L ! ! ! ! +-6xbu_A ! ! +-11 +-5 --------------NA--KG--------RC--NT--------QC--------------------------------------------------QG--------HC-------------- L ! ! ! ! +-4x0p_B ! ! ! ! --------------KT----------------------EG--KGYGACYCAC--------RC--------------------AT----RT--NG----QG----HC-------------- L ! ! +---13 +-----4xvk_A +-19 ! ! ! ----------------KC----------RT--NG--------TC----YCMCSA----HARAQAEA------------------------NG----QG---------------------- ! ! ! ! ! +-6fbc_A ! ! +--------15 +-----8 --------------------------------NA----------FC--YG----------RG----------------------------NG----QC---------------------- L ! ! ! +-1tau_A ! ! ! --------------------KT------RTNG--QG------------------------------------------------------------QA---------------------- ! ! +------------1x9m_A ! ! ----------------------------------------------------------------------------------------------------LTRT--HGDTFTRTRTNTFA L ! +-----------------------------2vih_B ! ----------------------------------------RT------------------------------VTQTNAMTKT-------------------------------------- L ! +1jgg_B ! +-1 ----------------------------------------RT----------------------------KTIAQCNA------------------------------------------ L +-20 +------4 +1ig7_A ! ! ! ! ------------------------------------------------------------------------ITQTNAMG---------------------------------------- L ! ! ! +5zjt_E ! ! +--12 ------------------------------------------------------------------------VAQTNA------------------------------------------ L ! ! ! ! +-1fjl_B ! ! ! +----6 ------------------------------------------------------------------------IAKGNA------------------------------------------ L ! ! +----------------14 ! +2hdd_A ! ! ! ! +-2 ------------------------------------------------------------------------IA--NA------------------------------------------ ! ! ! ! +4qtr_D +-21 ! ! ! ------------------------------------------------------------------------NT--NA--RG-------------------------------------- L ! ! +-18 +----------1b8i_B ! ! ! ----------------------------------------RA------------------------------IAQCNAMC---------------------------------------- L ! ! ! +4cyc_A ! ! ! +---------------3 ----------------------------------------RA------------------------------IAQTNA------------------------------------------ L +-22 ! +-----------16 +5ego_B ! ! ! ! ----------------------------------------RT----------------------------QTVAQTNA------------------------------------------ L ! ! ! +---------------3a01_F ! ! ! ----------------------------------------RT--------------------------RT--IAQCNA------------------------------------------ L +-23 ! +-----------------------------5jlw_D ! ! ! ----------------------------------------RC------------------------------IAQCNAYC---------------------------------------- L ! ! +-----------------------------3rkq_B -24 ! --------------------------------------------------------------------------KGNA------------------------------------------ L ! +-----------------------------2hos_A ! ----------------------------------------RT------------------------------VASGNA------------------------------------------ L +-----------------------------3cmy_A |
home
updated Mon Dec 18 11:48:01 2023