4y5w_B : 3D-footprint complex

structure name	TRANSCRIPTION FACTOR-DNA COMPLEX (Signal transducer and activator of transcription 6)
reference	Ouyang et al. Proc.Natl.Acad.Sci.USA 113 13015 2016
source	Homo sapiens
experiment	X-ray (resolution=3.10, R-factor=0.251)
structural superfamily	p53-like transcription factors;SH2 domain;STAT;
sequence family	STAT protein, DNA binding domain; STAT protein, allalpha domain; SH2 domain;
multimeric complexes	4y5w_AC 4y5w_BD 5d39_AC 5d39_BD
redundant complexes	5d39_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4y5w_B interface=203,240,241,243,244, kfktglrrlqhrvgeihllrealqkalamllqettgeleaakalvlkriqiwkrqqqlagngapfeeslaplqerceslvdiysqlqqevgaagtrasltgrldevlrtlvtscflvekqppqvlktqtkfqagvrfllglrflgapakpplvradmvtekqaretgeiinntvplensipgnccsalfknlllkkikrcerKgtesvteekcavlfsasftlgppiqlqalslplvviVHgNQdnnakatilwdnafsemdrvpfvvaervpwekmcetlnlkfmaevgtnrgllpehflflaqkifndnslsmeafqhrsvswsqfnkeillgrgftfwqwfdgvldltkrclrsywsdrliigfiskqyvtslllnepdgtfllrfsdseiggitiahvirgqdgspqieniqpfsakdlsirslgdrirdlaqlknlypkkpkdeafrshykpeqmgkdgrgvpatikmtve
interface signature	KVHNQ

Estimated binding specificities ?

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# IC=4.434 IC/col=0.443 n_of_columns=10

specificity:

A |   0  13  96  54  24  24  24  24  24  96
C |   0  13   0  16  24  24  24  24  24   0
G |  96  54   0  13  24  24  24  24  24   0
T |   0  16   0  13  24  24  24  24  24   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: STAT6
CTTCNNNGAAG	PubMed	5d39_AC(1.50e-04), 5d39_BD(1.51e-04)
TTCCNNGGAA	PubMed	4y5w_AC(2.12e-03), 5d39_AC(3.94e-04), 5d39_BD(3.98e-04), ... (total=4)
TTTCNNNGAAA	PubMed	5d39_AC(1.50e-04), 5d39_BD(1.51e-04)
ATTCCTAGAAAG	PubMed	5d39_AC(6.33e-06), 5d39_BD(5.47e-09), 5d39_B(7.18e-03)

Dendrogram of similar interfaces ?

matrix format

  
  ----KA--VTHG--NTQT   L                    +------4y5w_B    
                           +----------------2 
  KCEC----STNTVGSTQT   L   !                !     +1bf5_A    
                         --3                +-----1 
  --------STNT----QT       !                      +1bg1_A    
                           ! 
  RG----RTVCDC----RG   L   +-----------------------3wu1_A

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updated Tue Dec 19 09:45:51 2023