4xqk_A : 3D-footprint complex

structure name	ATP-DEPENDENT TYPE ISP RESTRICTION-MODIFICATION ENZYME LLABIII BOUND TO DNA (LLABIII)
reference	Saikrishnan et al. Nat.Chem.Biol. 11 870 2015
source	LACTOCOCCUS LACTIS SUBSP. CREMORIS
experiment	X-ray (resolution=2.70, R-factor=0.221)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;P-loop containing nucleoside triphosphate hydrolases;Restriction endonuclease-like;
sequence family	Type III restriction enzyme, res subunit; Helicase conserved Cterminal domain;
multimeric complexes	4xqk_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4xqk_A interface=350,807,958,960,961,964,966,995,996,998,1058,1059,1063,1074,1076,1077,1171,1218,1258,1259,1261,1300, kqtfddlinqintgtlfekltlaylkneptykalyqnvwllsevpesygipvdlvaeqkngdlvaiqakfytnkvgkseinsfvaelgksyyqrglivstmddwnsnaretidqnekgieiiglsdlrnsqidwsqfnferpenvvvkkpkklrdyqqtakenalahfkendrgqlimapgtgktftslkisealskdkdgpfkvlylvpsiqlltqtlrgwnndteltmtsmavtstedikasdigypattsskkilqnwhdfeslpkqtdmlvvfstyqsievigeaqkegfpefdfiisdeahrttgaheaakeasafskvhsnnnvkglkrmyqtatpkiygesaKknakdksillssmddeskygevffrmgfgqavsrdiltdykvmvlavdeaaiqkdmqrtladpenglniddvgrivgiwngmmrrngykknspydgapleraiaftrtieeskkvssqfeevvneyisihlsmrhadgqmnalqkgevldwlanpnkpadearivsnvrfltegidiptldaviflspkksqvdivqavgrimrkaegkdygyiilpiviptgekpetildnnknyetvwqvinalrsvderfeamidklnmakpkqlkvigvgsspdtelefewdkfegaifgkivqkvgdrkylenwskdvakiaerqinwiknklsdkkdpislefkkfvsslqhnindsidekqaaemlsqhlitkpifealfseysfvnqnpvsqamesivselekagfakeqenleplyesvrmraegiekaedkqkiivtlydkffktafkatterlgiVftpievvdfivhsvddvlkkhfgkslaskdvhildpftgtgtfivrtltylkeqmdageisladitrkfmkelhaneivllsyyiaainiestfdeingdeegyvpfegivltdtfestetedtldddyfgtnderlkrqqkvpitvimgNpPYsaKqKnedgnqirttyekldaslqnswvetstaTNkNnlfdsyiramrwssdrisdngvigfitnnsfidgnamdgmrqslleefsdiyvlnlkggIRgktKdqsaleggniFdIMtgvtiimlikksdytvegrihyldignnldkyqkleklknwkslngatsefqniipnekgdwinqrnsnfdelislgnkkgsdslfidytgglKtgrdnwswnfskeqvelsmkssidyynqylgdtniykedvpdiswtRslkqrferretqswqgermylgmyrpftkkhvyyaqawiDRqYqmtkvlpsstssnlmislsnktggkqfstlivdvlpdvNlftggsqnlpkylyrnndtgnlfdnsekysairhevlnklpnlseedamyyvyglfhsiqygkvyyedlaksfpkipnvkhkekyikigkeladlhlnyenqpicegidvqiselnyrvkkmkhpkkgvldtiiynesitiknipekayeyvvngrpaiewiinqyqvktdkksgitddpnefsddpkyilnlllsvitvsmrtlelidelpefeiq
interface signature	KVNPYKKTNNIRKFIMKRDRYN

Estimated binding specificities ?

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# IC=11.152 IC/col=0.558 n_of_columns=20

specificity:

A |  21  21  24  24  24  24  24  24  24  24  24  24   0   0   0  96   0   0   0   0
C |  42   0  24  24  24  24  24  24  24  24  24  24  96   0   0   0   0  96  96   0
G |  10  21  24  24  24  24  24  24  24  24  24  24   0   0  96   0  96   0   0  96
T |  23  54  24  24  24  24  24  24  24  24  24  24   0  96   0   0   0   0   0   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: LLABIII
TNAGCC	PubMed	4xqk_A(7.69e-04), 4xqk_AB(7.69e-04)

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updated Tue Dec 19 09:42:06 2023