interface graph thumbnail
legend  pdf

structure nameKSHV LANA (ORF73) C-TERMINAL DOMAIN MUTANT BOUND TO LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)
(ORF 73)
referenceHellert et al.
sourceHUMAN HERPESVIRUS 8
experimentX-ray (resolution=2.87, R-factor=0.123)
structural superfamilyViral DNA-binding domain;
multimeric complexes4uzb_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHPRYK

Estimated binding specificities ?

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# IC=5.830 IC/col=0.530 n_of_columns=11 specificity:   
A |   0   0   0   0  24  24  24  24  24  12   0
C |  96   0   0  24  24  24  24  24  24  24   0
G |   0  96  96  48  24  24  24  24  24  48  96
T |   0   0   0  24  24  24  24  24  24  12   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  HGPCRG--KG----------------------------------   L                 +-----4uzb_B    
                                                     +-------------1 
  ------NTKGFTKTTGYCNGRT----------------------   L   !             +-----1b3t_A    
                                                   --3 
  ----------------------LAKATGTGSGVGFA--RAECTA   L   !         +---------5tkz_B    
                                                     +---------2 
  ------------------------------------LG------                 +---------6dgd_B    
                                                   

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updated Tue Dec 19 09:32:38 2023