interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF KLEBSIELLA PNEUMONIAE PMRA IN COMPLEX WITH PMRA BOX DNA
(DNA-binding transcriptional regulator BasR)
referenceHsiao et al. 'Nat 6 8838 2015
sourceKlebsiella pneumoniae
experimentX-ray (resolution=3.20, R-factor=0.183)
structural superfamilyCheY-like;C-terminal effector domain of the bipartite response regulators;
sequence familyResponse regulator receiver domain; Transcriptional regulatory protein, C te;
multimeric complexes4s04_EF 4s05_AB
redundant complexes4s05_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNVR

Estimated binding specificities ?

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# IC=7.625 IC/col=0.953 n_of_columns=8 specificity:   
A |   0  96  75   0   7  73  73   0
C |   0   0   7   0  73   7   7   0
G |   0   0   7  96   9   9   7  96
T |  96   0   7   0   7   7   9   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PMRA
CTTAATPubMed4s04_B(6.35e-03), 4s05_AB(3.71e-04), 4s05_A(2.61e-07)
CCTAAGPubMed4s04_B(6.35e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ------------------RGDTVTSTRG----WT--   L                         +-------------6lxn_A    
                                                   +---------------1 
  ----------------------------YGRG----           +-2               +-------------4wcg_A    
                                                 ! ! 
  --------------QA------------------NG         +-3 +-----------------------------7k63_U    
                                               ! ! 
  ----------------RC------------------       +-4 +-----------------------------6l9z_S    
                                             ! ! 
  FTDTITVTAT--IT----------------------   L --5 +-----------------------------3zh2_C    
                                             ! 
  ----------ET------------------------       +-----------------------------7aud_E    
                                           

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updated Fri Jun 16 02:18:49 2023