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structure nameCRYSTAL STRUCTURE OF RUNX1 AND ETS1 BOUND TO TCR ALPHA PROMOTER (CRYSTAL FORM 3)
(RUNT-RELATED TRANSCRIPTION FACTOR 1)
referenceLeukemia 28 2040 2014
sourceMUS MUSCULUS
experimentX-ray (resolution=2.30, R-factor=0.231)
structural superfamilyp53-like transcription factors;
sequence familyRunt domain;
multimeric complexes3wu1_AB 4l18_AB 4l18_EF
redundant complexes1h9d_C 1hjc_D 3wu1
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRVDRR

Estimated binding specificities ?

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# IC=7.412 IC/col=0.927 n_of_columns=8 specificity:   
A |  78  78   6   0   0  78   0  78
C |   6   6   6  96  96   6  96   6
G |   6   6  78   0   0   6   0   6
T |   6   6   6   0   0   6   0   6
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: AML-1
CCCCAPubMed4l18_E(9.72e-03)
TGGGGPubMed4l18_E(9.72e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RGRTVCDCRG--   L                                 +4l0y_A    
                                                 +-1 
  RGRTVCDCRG--   L         +---------------------2 +3wu1_A    
                           !                     ! 
  RGRGVCDCRGRG   L   +-----3                     +-1h9d_A    
                     !     ! 
  KC----------   L --4     +-----------------------1bf5_A    
                     ! 
  ----RT------   L   +-----------------------------1gji_A    
                   

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updated Tue Dec 19 09:04:27 2023