4bwj_A : 3D-footprint complex

structure name	KLENTAQ MUTANT IN COMPLEX WITH DNA AND DDCTP (DNA POLYMERASE I, THERMOSTABLE)
reference	Diederichs et al.
source	THERMUS AQUATICUS
experiment	X-ray (resolution=1.55, R-factor=0.161)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family A; Taq polymerase, exonuclease;
redundant complexes	5w6q 3rrh 4dfk 3m8s 4dfm 4dfj 5nkl 4c8k 4elt 3t3f 3ktq 5w6k 1qsy 3sz2 1qss 3lwl 4dle 3rtv 3po4 4df4 3rr8 3rr7 4elv 4cch 4elu 4dlg 4c8n 4ktq 3ojs 3lwm 5o7t 5e41 4df8 3rrg 3m8r 3py8 4c8l 3po5 1tau 4bwm 4dfp 5oxj 4xiu 3syz 3sv3 4n56 4c8m 1qtm 3sv4 4n5s 5szt 2ktq 3oju 4c8o
reference complex	6fbc_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4bwj_A interface=247,251,280,287,290,371,374,378,380,384,457,461,491, leeapwpppegafvgfvlsrkepmwadllalaaarggrvhrapepykalrdlkeargllakdlsvlalreglglppgddpmllaylldpsnttpegvarryggewteeageraalserlfanlwgrlegeerllwlyreverplsavlahmeatgvrldvaylramslevaeeiarleaevfrlaghpfnlnsrdqlervlfdelglpaigktektgkrstraavlealreahpivekilqyreltKlksTyidplpdlihprtgrlhtrfnqtatatgRlsssdpNlqNipvrtplgqrirrafiaeegwllvaldysqielrvlahlsgdenlirvfqegrdfhtetaswmfgvpreavdplmrraakTinFgvlYgMsahRlsqelaipyeeaqafieryfqsfpkvrawiektleegrrrgyvetlfgrrryvpdlearvksvreaaerkafNmpvQgtaadlmklamvklfprleemgarmllqvHdelvleapkeraeavarlakevmegvyplavplevevgigedwlsake
interface signature	KTRNNTFYMRNQH

Estimated binding specificities ?

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# IC=2.703 IC/col=0.676 n_of_columns=4

specificity:

A |  19   8   0  11
C |   8  72   0  69
G |  61   8  96   8
T |   8   8   0   8

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --------------KC------------RGNGNG----TGFG--YGMG----RG------KASAEARANGQGHG   L                          +--4bwj_A    
                                                                                                        +-2 
  --------------KT----YG------RGNGNGRC----YG--YAIGSCYC--NGRC--FG--------QAHG                            ! ! +-4yfu_D    
                                                                                                      +-3 +-1 
  LCNGKGYGMGEG----------SGHGVC----------------------------------------------                          ! !   +-1kln_A    
                                                                                   +------------------4 ! 
  --------------NA--KA--------RG--NT----QC----YCMC------QC--NGPTYGATRT--QC--       !                  ! +----4x0q_B    
                                                                                 --5                  ! 
  --------------KT------------RG------EGKGYGACYCAC----RC--------QTATRTNGQGHC   L   !                  +-----4xvk_A    
                                                                                   ! 
  ------------SC--EG--------------------QG--TGYGVG--YT----------------------   L   +------------------------4boc_A

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updated Mon Dec 18 09:50:27 2023