interface graph thumbnail
legend  pdf

structure nameMITF:M-BOX COMPLEX
(MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR)
referencePogenberg et al. 'Genes 26 2647 2012
sourceMUS MUSCULUS
experimentX-ray (resolution=2.60, R-factor=0.230)
structural superfamilyHLH, helix-loop-helix DNA-binding domain;
sequence familyHelixloophelix DNAbinding domain;
multimeric complexes4ati_AB 4atk_AB
redundant complexes4atk
reference complex6g1l_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHNIERR

Estimated binding specificities ?

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# IC=2.959 IC/col=0.493 n_of_columns=6 specificity:   
A |  10  19   8   0  12  10
C |  10  20   8   0  60  10
G |  10  38  10  96  12  13
T |  66  19  70   0  12  63
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: M-box
CATGTGPubMed4ati_B(1.13e-03), 4ati_AB(1.18e-08), 4atk_AB(3.29e-04)
GTGTGAPubMed4ati_B(1.13e-03), 4ati_AB(1.02e-02)
GTCATGTGCTPubMed4ati_B(2.59e-08), 4ati_AB(7.77e-16), 4atk_AB(1.07e-06), ... (total=4)
CACGTGPubMed4ati_AB(3.30e-04), 4atk_AB(1.18e-08), 4atk_B(3.56e-04)
term: MITF
CANNTGPubMed4ati_AB(1.02e-02), 4atk_AB(1.02e-02)
CATGTGPubMed4ati_B(1.13e-03), 4ati_AB(1.18e-08), 4atk_AB(3.29e-04)
CACCTGPubMed4ati_AB(3.30e-04), 4atk_AB(3.29e-04)
TGTGGTCPubMed4ati_B(6.94e-05), 4ati_AB(2.13e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ------HGNT--IAEC----RCRT----   L                   +4ati_B    
                                                   +-1 
  KT----HGNT----EC----RCRG----   L               +-4 +1nkp_A    
                                                 ! ! 
  ------HGNT--LGEC----RCRC----   L             +-5 +5i50_B    
                                               ! ! 
  ------HGNT----EC----RCRG----   L   +---------6 +--1nkp_E    
                                     !         ! 
  ------HGNT--MTEA----RCRG----   L   !         !    +1nlw_D    
                                     !         +----2 
  ----------HG----IAEC----YCRG   L --9              +1am9_A    
                                     ! 
  --RT----NT--RGEC----RCQT----       !        +-----2ypa_A    
                                     !        ! 
  ------HGST--ITET----RCRG----   L   +--------8     +4h10_A    
                                              ! +---3 
  ------HG----ITEC----RCRG----   L            +-7   +5nj8_D    
                                                ! 
  ----QG------VTEC----RCRG----   L              +----1an4_A

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updated Mon Dec 18 09:46:04 2023