structure nameCRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL TRANSCRIPTION FACTOR A, TFAM OR MTTFA, BOUND TO THE LIGHT STRAND PROMOTER LSP
(Transcription factor A, mitochondrial)
referenceJimenez-Menendez et al. Nat.Struct.Mol.Biol. 18 1281 2011
sourceHomo sapiens
experimentX-ray (resolution=2.45, R-factor=0.183)
structural superfamilyHMG-box;
sequence familyHMG high mobility group box;
multimeric complexes3tq6_AB 6erp_ACF 6erp_BGJ 6erq_ACF 6erq_BGJ 6hb4_ADGJ 6hc3_ADGJ 7lbw_AB
redundant complexes6hb4_J 6hc3_D 7lbw_B 7lbx_B 6erp 6erq
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSYLSLTTIRMKRSYNVFPQL

Estimated binding specificities ?

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# IC=12.344 IC/col=0.771 n_of_columns=16 specificity:   
A |  84   0  96   0  11  11  73  24  24  24  24   0   0  96  96   5
C |   5  96   0   0   5  67  13  24  24  24  24  90  96   0   0  81
G |   5   0   0  96   7   5   5  24  24  24  24   6   0   0   0   5
T |   2   0   0   0  73  13   5  24  24  24  24   0   0   0   0   5
scan!

Dendrogram of similar interfaces ?

matrix format
  
  KA--STYGLASGLA--TGTC--IT------KGRTYANTVTFGPGQCLC   L                    +----------------3tmm_A    
                                                               +----------6 
  RC--NTFTMA--RAHGNAAC--ST------------------------   L         !          +----------------4euw_A    
                                                               !  
  ----STYGLASGLA--TGTC--IT--RAMTKGRGYANTVTFGPGQCLC   L         !           +----------------3tq6_B    
                                                            +-11    +------7 
  RT--NGFTMA--RT--NTAT--SA------------------------   L      !  !  +-9      +----------------6t78_A    
                                                            !  !  ! ! 
  RT--NGFTIA--RA--NASG--ST------------------------   L      !  !  ! +-----------------------1j47_A    
                                                            !  +-10  
  RT--NAFTIA--RA--NT----SA------------------------   L      !     !                         +6edb_B    
                                                            !     !          +--------------1 
  RC--NGFTMA--RTHTNG----ST------------------------   L      !     +----------4              +6t90_L    
                                                         +-12                ! 
  RC--NTFTMA--RAHGNT----SA------------------------   L   !  !                +--------------3f27_D    
                                                         !  !  
  RT--NAFA----RCDTNTRA--ST------------------------   L   !  !                           +6jrp_D    
                                                         !  !           +---------------2 
  KC--NT--MAMA--EGSAAC--NT------------------------   L   !  !           !               +2lef_A    
                                                       -13  !      +----5 
  RTTASTYAFALT----PTAT--STRA----------------------   L   !  !      !    ! +-------------5jh0_D    
                                                         !  +------8    +-3 
  ----NAFTIA--RC----SGICST------------------------   L   !         !      +-------------1hry_A    
                                                         !         ! 
  --------FTCA----IG----AT------------------------       !         +--------------------6oem_H    
                                                         !  
  ------YA--------FT----SG------------------------       +----------------------------5ze0_N    
                                                       

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updated Tue Dec 19 08:12:23 2023