| structure name | NKX2.5 HOMEODOMAIN DIMER BOUND TO ANF-242 DNA (Homeobox protein Nkx-2.5) |
| reference | Kasahara et al. Biochemistry 51 6312 2012 |
| source | Homo sapiens |
| experiment | X-ray (resolution=1.70, R-factor=?) |
| structural superfamily | Homeodomain-like; |
| sequence family | Homeobox domain; |
| multimeric complexes | 3rkq_AB 4s0h_AB 4s0h_EF |
| redundant complexes |  4s0h_B
|
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | RIQNY |
Estimated binding specificities ?
| contact |  |
A | 6 6 0 0 0 24 66 C | 78 0 90 0 18 0 0 G | 6 0 0 0 6 60 24 T | 6 90 6 96 72 12 6scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: NKX2.5 | ||
| CAAGTG | PubMed | 3rkq_B(7.04e-05), 3rkq_AB(5.82e-04), 4s0h_EF(2.07e-04), ... (total=5) |
| TNNAGTG | PubMed | 3rkq_AB(6.04e-03), 4s0h_B(1.14e-02) |
Dendrogram of similar interfaces ?
matrix format--KG--RT------------------IAQCNAYA-- L +1nk2_P +--------------3 RC----RT------------------ITQCNAACRG L ! ! +6a8r_A ! +-1 --RC--RT------------------NT--NAITRG +----9 +5zjt_B ! ! ----RC----RT--------------NCSTNARG-- L ! ! +1mnm_C ! +--------------4 ------RT------------------NT--NAIARG L ! +1b72_B +-10 ------RT------------------VAQTNA---- L ! ! +5hod_A ! ! +---------2 --RT--RT------------------IAKGNA---- L ! ! +---7 +6m3d_C ! ! ! ! ------------------------RTVAITNAMCRG L ! +-----8 +----------1yrn_A +-11 ! ------RT----------------FTYAQTNAATRG L ! ! ! +----6ryd_F ! ! +---------6 ------------------------RCVACTNAQA-- L ! ! +----7xrc_C +-12 ! ------RA----------------RCVTCTNAQTRC L ! ! ! +--1au7_A ! ! +--------------------5 ------RT----------STVC--KGDCRG------ L +-13 ! +--1w0t_A ! ! ! ------RA------------------YAQTNAAARG L ! ! +------------------------6wig_A +-14 ! --------NGRGTGLG----LC-------------- ! ! +-------------------------6vjw_A +-15 ! --------NGRGTGLG----LCRG------------ ! ! +--------------------------7kz0_A -16 ! RT----RT------------------VAQTNA---- L ! +-----------------------------1fjl_B ! ----------------STRGQTQAST---------- L +-----------------------------7t8k_B |
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updated Tue Dec 19 08:06:39 2023