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legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF FOXO4 BOUND TO DNA
(Forkhead box protein O4)
referenceObsilova et al. 'Acta 66 1351 2010
sourceHomo sapiens
experimentX-ray (resolution=1.87, R-factor=0.195)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSNSRHS

Estimated binding specificities ?

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# IC=4.747 IC/col=0.791 n_of_columns=6 specificity:   
A |   6   6   6   0   6  78
C |   6   6   6   0   6   6
G |   6  78   6   0   6   6
T |  78   6  78  96  78   6
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: FOXO4
TTGTTTACPubMed3l2c_A(1.35e-11)

Dendrogram of similar interfaces ?

matrix format
  
  ------------------NAST--RTHT----ST----------                     +-----------------------------3co7_C    
                                                                 +-1 
  ------------------NAST--RGHT----STLT--------   L             +-2 +-----------------------------7cby_C    
                                                               ! ! 
  ------------------NAST--RGHTNT--STLT--------   L           +-3 +-----------------------------7fj2_B    
                                                             ! ! 
  ----------------NAST--RGHTNT--STLA----------   L         +-4 +-----------------------------2hdc_A    
                                                           ! ! 
  ----RC--------------------------------------           +-5 +-----------------------------7cow_T    
                                                         ! ! 
  ------------KGTA----TA------RG--------------   L     +-6 +-----------------------------1xsd_A    
                                                       ! ! 
  ------LTNTHG--RT--YTPT----------------------   L   +-7 +-----------------------------6qil_A    
                                                     ! ! 
  KAFA--------------------------------YANAFGMC     --8 +-----------------------------3aaf_B    
                                                     ! 
  --------------------NT--RGCT----NGST--------   L   +-----------------------------1if1_B    
                                                   

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updated Tue Dec 19 07:47:34 2023