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structure nameCLASSIC PROTEIN WITH A NEW TWIST: CRYSTAL STRUCTURE OF A LEXA REPRESSOR DNA COMPLEX
(LexA repressor)
referenceZhang et al. Nature 466 883 2010
sourceEscherichia coli K-12
experimentX-ray (resolution=2.29, R-factor=0.268)
structural superfamilyLexA/Signal peptidase;"Winged helix" DNA-binding domain;
sequence familyLexA DNA binding domain; Peptidase S24like;
multimeric complexes3jso_AB 3jsp_AB
redundant complexes3jsp_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRSPNAEE

Estimated binding specificities ?

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# IC=8.008 IC/col=0.890 n_of_columns=9 specificity:   
A |   0   0   0   2  90   7  34   2  84
C |  96   0   0  40   2  17  19   0   4
G |   0   0  96   2   0  14  20   1   8
T |   0  96   0  52   4  58  23  93   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: LexA
GCTACTGTATGTPubMed3jso_B(2.00e-06), 3jso_AB(1.16e-03), 3jsp_A(3.07e-05)
TGTACAAATGTACAPubMed3jso_B(1.66e-03), 3jso_AB(1.63e-10)
CTGTATATPubMed3jso_B(3.19e-13), 3jso_AB(9.07e-11), 3jsp_A(3.92e-06)
CTGTATATATACCCAGPubMed3jso_B(1.64e-12), 3jsp_A(7.32e-05)
CTGTATATATATACAGPubMed3jso_B(1.64e-12), 3jsp_AB(2.15e-04), 3jsp_A(7.32e-05)
GAACAGGTGTTCPubMed3jsp_A(1.12e-02)
TACTGPubMed3jsp_A(1.95e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ------------------YGRG------                 +-----------------------------4wcg_A    
                                             +-1 
  QA------------------------NG             +-2 +-----------------------------7k63_U    
                                           ! ! 
  --RC------------------------           +-3 +-----------------------------6l9z_S    
                                         ! ! 
  ----------------RCYG--KT----         +-4 +-----------------------------2acj_B    
                                       ! ! 
  ----------TTHT--KG------RC--   L   +-5 +-----------------------------7b0c_A    
                                     ! ! 
  ----RC--------------------SG     --6 +-----------------------------7cow_T    
                                     ! 
  ------SGRGPT--SGRG----------   L   +-----------------------------7bhy_A

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updated Tue Dec 19 07:41:04 2023