| structure name | CRYSTAL STRUCTURE OF FOXO1 DBD BOUND TO DBE1 DNA (Forkhead box protein O1) |
| reference | Marmorstein et al. Structure 16 1407 2008 |
| source | Homo sapiens |
| experiment | X-ray (resolution=2.10, R-factor=?) |
| structural superfamily | "Winged helix" DNA-binding domain; |
| sequence family | Fork head domain; |
| multimeric complexes | 4lg0_AB 5dui_AB 6lbi_CD 6lbi_GH 6lbi_KL |
| redundant complexes |  3co7_F
3coa_C
5dui_A
6lbi_G
4lg0
|
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | NSRHNSL |
Estimated binding specificities ?
| readout + contact |  |
A | 9 13 6 0 1 82 C | 6 13 6 0 6 0 G | 6 61 6 0 0 14 T | 75 9 78 96 89 0scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: FOXO1 | ||
| TGAGATGTTTTGAAAG | PubMed | 3co6_C(3.69e-04) |
| GTAAACAA | PubMed | 3co6_C(3.67e-09), 5dui_A(1.82e-03) |
| CAAAACA | PubMed | 3co6_C(6.27e-06) |
| AATAACA | PubMed | 3co6_C(3.38e-03) |
| ATAAACA | PubMed | 3co6_C(8.33e-10), 5dui_A(1.03e-03) |
| GTAAACA | PubMed | 3co6_C(8.33e-10), 5dui_A(1.03e-03) |
| CAAAACAAAACA | PubMed | 3co6_C(1.61e-04) |
Dendrogram of similar interfaces ?
matrix format----------------------NAST--RTHT----ST-------------- +-----------------------------3co7_C ! ----------------------NAST--RGHTNT--STLT------------ L ! +7fj2_B +-6 +----------------1 --------------QT----NAST--RGHTNT--STLA-------------- L ! ! +----------3 +2hdc_A ! ! ! ! ------------------------RC----YG--------KT---------- ! ! ! +----------------2acj_B ! +-5 ----KAFA----------------------------------YANAKTFGMC +-7 ! +-----------3aaf_B ! ! ! +---------2 ----------LTNTHG--RT--YTPT----------------------RT-- L ! ! +-----4 +-----------6qil_A ! ! ! --RC------------------------------------------------ +-8 ! +---------------------6l9z_S ! ! ! ----------------------NAST--RGHT----STLT------------ L ! ! +-----------------------------7cby_C +-9 ! ----------------------------RGHT----ST-------------- L ! ! +-----------------------------6akp_C +-10 ! --------RC------------------------------------------ ! ! +-----------------------------7cow_T +-11 ! ----------YAKTPTPG----YTRG-------------------------- L ! ! +-----------------------------4mtd_D +-12 ! ------------------------NT--RGCT----NGST------------ L ! ! +-----------------------------1if1_B +-13 ! ----------------KGTA----TA------RG------------------ L ! ! +-----------------------------1xsd_A -14 ! NC--------------------TT----RGCT----NGKG------------ L ! +-----------------------------7rh2_B ! ----------------------TT----RTCT----NGKG------------ L +-----------------------------7oot_B |
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updated Tue Dec 19 07:13:56 2023