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structure nameCRYSTAL STRUCTURE OF THE BZIP HETERODIMERIC COMPLEX MAFB:CFOS BOUND TO DNA
(PROTO-ONCOGENE PROTEIN C-FOS)
referencePogenberg et al. Structure 22 466 2014
sourceMUS MUSCULUS
experimentX-ray (resolution=2.30, R-factor=0.230)
structural superfamilyA DNA-binding domain in eukaryotic transcription factors;
sequence familyBasic region leucine zipper; bZIP transcription factor;
multimeric complexes1a02_FJN 1fos_EF 1fos_GH 1s9k_CDE 2wt7_AB
redundant complexes1a02 1fos 1s9k
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRNAACR

Estimated binding specificities ?

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# IC=4.046 IC/col=0.674 n_of_columns=6 specificity:   
A |  69  24   9   0  96   9
C |   9  24  11  96   0   9
G |   9  24   9   0   0   9
T |   9  24  67   0   0  69
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: FOS
TGACTCAPubMed2wt7_A(1.06e-03), 1fos_EF(1.21e-12), 1fos_GH(1.66e-04), ... (total=4)
CGAGTCAPubMed1fos_EF(2.69e-08), 2wt7_AB(6.74e-04)
TGAGTCAPubMed2wt7_A(1.06e-03), 1fos_EF(1.21e-12), 1fos_GH(1.66e-04), ... (total=4)
GTGACTAAPubMed1fos_EF(2.15e-06), 2wt7_AB(1.09e-02)
ATTAATCATPubMed1fos_EF(9.05e-03)
ACGTCAPubMed1fos_EF(3.56e-03)
TGACTCAGPubMed2wt7_A(1.87e-03), 1fos_EF(1.45e-11), 1fos_GH(6.12e-04), ... (total=4)
GGTCAPubMed1fos_EF(1.07e-03)
TGGGTCAPubMed1fos_EF(4.71e-07), 2wt7_AB(3.45e-03)
TGACTGAPubMed1fos_EF(4.52e-07), 2wt7_AB(3.45e-03)
TGCTGACTCAGCAPubMed2wt7_A(8.96e-03), 1fos_EF(1.86e-09), 1fos_GH(8.26e-03), ... (total=4)
TGAGCAAPubMed2wt7_A(1.06e-03), 1fos_EF(2.28e-03), 2wt7_AB(3.45e-03)
TGAGCCAPubMed2wt7_A(1.06e-03), 1fos_EF(5.32e-07), 2wt7_AB(3.45e-03)
TGATTCAPubMed1fos_EF(3.87e-07), 2wt7_AB(3.45e-03)
ATGAGTCACPubMed2wt7_A(3.07e-03), 1fos_EF(8.66e-11), 1fos_GH(1.50e-03), ... (total=4)
TGACACAPubMed1fos_EF(4.14e-07), 2wt7_AB(3.45e-03)
CGTCAPubMed1fos_EF(1.07e-03)
TGACGTPubMed1fos_EF(3.56e-03)
CTGACTCATPubMed2wt7_A(3.07e-03), 1fos_EF(8.66e-11), 1fos_GH(1.50e-03), ... (total=4)
sitesourcematches (E-value)

Dendrogram of similar interfaces ?

matrix format



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updated Tue Dec 19 07:01:57 2023