2pi0_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF IRF-3 BOUND TO THE PRDIII-I REGULATORY ELEMENT OF THE HUMAN INTERFERON-B ENHANCER (Interferon regulatory factor 3)
reference	Nistal-Villan et al. Mol.Cell 26 703 2007
source	Homo sapiens
experiment	X-ray (resolution=2.31, R-factor=0.185)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Interferon regulatory factor transcription f;
multimeric complexes	1t2k_ABCD 2o6g_EFGH 2pi0_ABCD
redundant complexes	1t2k_A 2o6g_H
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2pi0_B interface=40,42,78,79,81,82,85,86, mgtpkprilpwlvsqldlgqlegvawvnksrtrfripwkHgLrqdaqqedfgifqawaeatgayvpgrdkpdlptwkRNfRSalNRkeglrlaedrskdphdphkiyefvns
interface signature	HLRNRSNR

Estimated binding specificities ?

readout + contact

# IC=6.249 IC/col=0.694 n_of_columns=9

specificity:

A |  56  24  24  16   0  96  96  96   8
C |  16  24  24  16   0   0   0   0  16
G |  16  24  24   8  96   0   0   0  64
T |   8  24  24  56   0   0   0   0   8

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: IRF-3
AANNGAAA	PubMed	2pi0_B(1.87e-03), 2o6g_EFGH(6.46e-04), 2pi0_ABCD(6.19e-04)

Dendrogram of similar interfaces ?

matrix format

  
  ECKT----RGAT--RGHT----RA--   L                                  +---4mhg_A    
                                                                +-1 
  --KT----RG----RGYT--------   L       +------------------------2 +---4bqa_A    
                                       !                        ! 
  --KT----RG----RGYA--------   L     +-3                        +----4l18_B    
                                     ! ! 
  ------NAST--RGHT--ST------   L   +-4 +-----------------------------2uzk_A    
                                   ! ! 
  ----NAST----RTHT--ST------   L --5 +-----------------------------3l2c_A    
                                   ! 
  ----NAST----RGHT--STLT--KA   L   +-----------------------------2c6y_A

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updated Tue Dec 19 06:50:47 2023